Implementing Innovative and Strategic Approaches to Prevent and Mitigate the Deleterious Effects of HPV Across the Lifespan of Hispanics of Mexican origin

摘要 拟议的行为研究项目使用创新的方法来解决西班牙裔癌症健康问题 人乳头状瘤病毒（HPV）感染的风险HPV持续感染，最常见的 在美国，性传播感染会增加多种癌症的风险。接种HPV疫苗 因此，疫苗接种是预防癌症的一个关键因素，但全国的疫苗接种率仍然很低。在大多数情况下- 相比之下，德克萨斯州埃尔帕索县的西班牙裔人口， 青少年是全国最高的。这一群体尚未得到系统的调查， 确定影响HPV疫苗接种率的具体促进因素和障碍。此外，人们对 成人的疫苗接种或HPV意识，提供了关注HPV和癌症的绝佳机会 预防贯穿整个生命周期。该项目的目的是评估HPV相关知识、态度和 在大多数西班牙裔社区样本中的实践，确定疫苗吸收和使用的障碍和促进因素， 有针对性的干预措施，以改变这一服务不足的人口的行为。我们的假设是 疫苗接种、筛查和健康素养将减少与HPV感染相关的西班牙裔癌症健康差异。 从拟议的研究结果将显着推进该领域，并扩大目前的知识因素 影响疫苗的可接受性。我们将提供定量的，高分辨率的社会文化分析， 阻碍或促进接受HPV疫苗的背景变量。我们专注于西班牙裔，因为这个群体 表现出增加的发病率和晚期癌症表现，但在研究中， 预防和早期诊断。通过我们的努力，我们将发现并开始解决具体的和以前的问题， 未知的疫苗接种障碍，增加已确定的疫苗接种促进因素，并制定干预措施， 在其他环境中也可以很容易地部署。拟议的项目增加了获得和参与研究的机会 主要由拉丁美洲人/a血统的人。美墨边境是一个独特而有价值的环境， 进行这项研究，因为我们两国社区的成员接触到不同的医疗保健标准 以及影响医疗决策的各种社会文化和其他影响。额外的力量 我们的计划是我们参与新兴的医疗保健提供者，社区卫生工作者和癌症 幸存者我们的观察可能会推广到美国其他地区， 特色我们的研究结果将为寻找改进HPV疫苗的靶向方法提供信息 在我们地区和其他地区增加癌症预防。

ABSTRACT The proposed Behavioral Research project uses innovative approaches to address Hispanic cancer health disparities associated with the human papillomavirus (HPV). Persistent infection with HPV, the most common sexually-transmitted infection in the US, elevates the risk for multiple types of cancer. Vaccination against HPV is thus a critical factor in cancer prevention, yet vaccine uptake across the country remains low. In the majority- Hispanic population of El Paso County, Texas, in contrast, the rates of first-dose HPV vaccine uptake in adolescents are among the highest in the nation. This group has not been systematically investigated to determine specific facilitators and barriers that impact HPV vaccination rates. Moreover, little is known about vaccine uptake or HPV awareness in adults, providing an outstanding opportunity to focus on HPV and cancer prevention across the lifespan. The objective of this project is to assess HPV-related knowledge, attitudes and practices in a majority-Hispanic community sample, identify barriers and facilitators of vaccine uptake, and use targeted interventions to modify behavior in this underserved population. Our hypothesis is that increased vaccination, screening, and health literacy will reduce Hispanic cancer health disparities related to HPV infection. Results from the proposed studies will significantly advance the field and extend current knowledge on factors that influence vaccine acceptability. We will provide quantitative, high-resolution analyses of sociocultural and contextual variables that impede or facilitate receipt of the HPV vaccine. We focus on Hispanics, as this group exhibits increased morbidity and late-stage cancer presentation, but is underrepresented in studies that facilitate prevention and early diagnosis. Through our efforts, we will discover and begin to address specific and previously unknown barriers to vaccination, augment identified facilitators of vaccine uptake, and develop interventions that are readily deployable in other settings. The proposed project increases access to and participation in research by persons of predominantly Latino/a origin. The US-Mexico border is a unique and valuable setting in which to conduct this research, as members of our bi-national community are exposed to different health care standards and diverse sociocultural and other influences that impact medical decision-making. An additional strength of our program is our engagement of emerging healthcare providers, community health workers, and cancer survivors. Our observations are likely to generalize to other regions of the US with similar ethnic or sociocultural characteristics. Findings from our studies will inform the search for targeted approaches to improve HPV vaccine uptake and increase cancer prevention in our region and beyond.