Behavior and Circuitry of Directed Orofacial Exploration

摘要-研究项目2 定向口面探索的行为和电路（Martin Deschênes，负责人;大卫克莱菲尔德） 这个研究计画考虑知觉问题沿着与控制电路的逆向工程 鼻毛设定点，即，触须的平均位置。控制可以发生在多个层面上。我们 关注两个层次的电路。一级回路包括脑干和中脑内的通路。 初步数据表明，参与的Köliker-Ehrman核和上级丘作为候选人 运动前区第二层回路由下行的感觉和运动皮层通路组成。 这两个层次的电路的作用也将研究有关偏转和节奏运动的 鼻子从运动皮层到触须运动区的自上而下的输入，可能还有鼻子运动区，脑干区 可能是同源的运动皮层控制的舌头（项目3）。这些数据与"接线图"有关。 以及运动前区和运动前2区通路的"信号通路"。 我们进一步考虑在一个开放的竞技场orofacial行动的协调。老鼠探索小说 环境中使用的测定，其中动物缓慢增加其覆盖范围和维度 搜索内置的传感器和记录电子设备将使我们能够监测运动动作的协调性 与动物觅食同时发生。 这些数据提供了一组连接，这些连接限制了口面神经激活和操作的模型。 探索性电路它们让我们深入了解自然界在网络设计中所做的操作权衡。 这些数据，沿着来自研究项目1和3的互补解剖学和电生理学数据， 作为研究项目5的一部分进行分析，为口面电路探索的理论分析提供输入 （项目4）。

Abstract - Research Project 2 Behavior and circuitry of directed orofacial exploration (Martin Deschênes, lead; David Kleinfeld) This Research Project considers perceptual issues along with reverse engineering of circuits for the control of vibrissa set-point, i.e., the mean position of the vibrissae. Control may occur on a multitude of levels. We focus on circuits at two levels. One level of circuitry comprises pathways within the brainstem and midbrain. Preliminary data suggests involvement of the Kölliker-Fuse nucleus and the superior colliculus as candidate premotor regions. A second level of circuitry is comprised of descending sensory and motor cortical pathways. The role of these two levels of circuitry will also be studied in relation to deflection and rhythmic motion of the nose. The top-down input from motor cortex to the vibrissa motor, and possibly nose motor, areas of brainstem may be homologous to motor cortex control of the tongue (Project 3). These data bear on the "Wiring diagram" and "Signal pathways" for premotor and pre2motor pathways. We further consider the coordination of orofacial actions in an open arena. Mice explore a novel environment using an assay in which the animal slowly increases both the coverage and dimensionality of its search. Indwelling sensors and logging electronics will allow us to monitor coordination across motor actions concurrent with the animals foraging. These data provide a set of connections that constrain models for the activation and operation of orofacial exploratory circuitry. They give insight into the operational tradeoffs that nature has made in network design. These data, along with complementary anatomy and electrophysiology data from Research Projects 1 and 3, analyzed as part of Research Project 5, provide input for a theoretical analysis of orofacial circuitry exploration (Project 4).