Penn PET Addiction Center of Excellence (Penn PACE)

总体摘要 这是一份修订后的申请申请，请求提供资源以创建NIDA P30卓越核心中心 宾夕法尼亚大学的项目专注于研究阿片类药物使用障碍的神经生物学 (ODS)。这个新中心将专注于对寻求治疗的患者进行正电子发射断层扫描(PET)研究。 在佩雷尔曼医学院成瘾研究中心(CSA)接受治疗。这个 宾夕法尼亚大学在两个关键领域有着悠久的历史，这两个领域是P30课程的基础 卓越中心，阿片类药物使用障碍新策略的开发，以及PET成像 对大脑功能的研究。拟建中心的名称是宾夕法尼亚大学宠物成瘾中心 卓越(宾夕法尼亚大学佩斯)，代表着放射科之间的合作努力 以及宾夕法尼亚大学的精神病学。这份修订后的申请中的一个关键补充是将耶鲁大学纳入 这个P30中心。该中心最初将专注于阿片类药物敏感性、成瘾和 自杀，以及氧化应激和神经炎症在ODS中的作用。这个中心利用 宾夕法尼亚大学和耶鲁大学的独特资源。中心的绩效指标 是布里顿·钱斯的放射学教授罗伯特·H·马赫博士，本杰明的亨利·克兰兹勒博士 拉什精神病学教授和约翰·格利克精神病学和副精神病学教授卡林·勒曼博士 宾夕法尼亚大学战略倡议学院院长。另一位关键人物是耶鲁大学的理查德·卡森博士 卡森博士将领导耶鲁大学的研究工作，并指导数据分析 成像核心的组件。他还与大卫·曼科夫博士共同担任影像核心部主任 在宾夕法尼亚大学。该中心由一个行政核心和三个研究核心组成：放射化学， 影像与临床核心。这个中心的中心是试点项目核心，它由一个小组组成 NIDA资助的调查员利用提供的机会确定的和潜在的试点项目 通过这个P30核心卓越中心项目来扩展他们的研究项目。我们预料到 宾夕法尼亚大学的步伐将使我们对神经生物学机制的理解取得重大进展。 阿片类药物使用障碍和神经炎症，只有通过联合使用 严格控制的临床试验与PET提供的独特分子成像特性相结合。

OVERALL ABSTRACT This is a revised application requesting resources to create a NIDA P30 Core Center of Excellence Program at the University of Pennsylvania focused on studying the neurobiology of opiate use disorders (OUDs). This new center will focus on Positron Emission Tomography (PET) studies in patients seeking treatment at the Center for the Studies of Addiction (CSA) at the Perelman School of Medicine. The University of Pennsylvania has a long history in two key areas that serve as the foundation of this P30 Center of Excellence, the development of novel strategies for the opiate use disorders, and PET imaging studies of brain function. The name of the proposed center is the Penn PET Addiction Center of Excellence (Penn PACE), and represents a collaborative effort between the Departments of Radiology and Psychiatry at Penn. A key addition to this revised application is the inclusion of Yale University in this P30 Center. The center will initially focus on opioid receptors in opioid sensitivity, addiction, and suicide, and the role of oxidative stress and neuroinflammation in OUDs. This center takes advantage of unique resources at both the University of Pennsylvania and Yale University. The PIs of the Center are Dr. Robert H. Mach, the Britton Chance Professor of Radiology, Dr. Henry Kranzler, the Benjamin Rush Professor of Psychiatry, and Dr. Caryn Lerman, the John Glick Professor of Psychiatry and Vice Dean for Strategic Initiatives at Penn. Another key person is Dr. Richard Carson of the Yale University PET Center; Dr. Carson will lead the research effort at Yale University and direct the data analysis component of the Imaging Core. He is also the Co-Director of the Imaging Core with Dr. David Mankoff at Penn. The center consists of an Administrative Core and three research cores: Radiochemistry, Imaging and Clinical Core. Central to this center is the Pilot Project Core, which consists of a panel of identified and potential pilot projects by NIDA-funded investigators who use the opportunities provided by this P30 Core Center of Excellence Program to expand their research programs. We anticipate that the Penn PACE will lead to a significant advance in our understanding of the neurobiological mechanisms of opiate use disorders and neuroinflammation in a manner only possible through the combination of tightly-controlled clinical trials coupled with the unique molecular imaging properties provided by PET.