Molecular Pathogenesis of Infectious Diseases

本申请是我们的跨学科博士前培训计划的第三次竞争性更新 在科罗拉多大学安舒茨分校的传染病分子发病机制（MPID） 医学院。26名教师在六个部门的附属机构为我们的学员提供机会， 研究允许RNA和DNA病毒，革兰氏阳性和阴性 细菌，结核分枝杆菌和原生动物寄生虫，导致发病率和死亡率， 全世界的人类。MPID学员可以获得基础，基因组，计算，翻译和 系统生物学研究。我们的培训教师已经证明了创新研究的生产力， 传染病，他们的实验室平均每年收到75万美元的事实说明， 直接成本。学生被选中后，他们完成了任命为这个培训计划 他们的必修课程，通过了他们的初步和全面的考试，并开始他们的 论文研究自2002年首次获奖以来，MPID计划资助了49名学生，占总人数的8%。 他们是代表性不足的少数民族。在过去的5年里，90%的学生隶属于MPID 培训计划获得了州外机构的本科学位。的实验室 培训教师从每年28名研究生扩大到平均每人3.4篇出版物 上一个资助期（2007-2013）的学生人数减少到每年约35人，平均4.6人 在过去的四年里，每个学生的出版物。除了完成课程和进行他们的 指导的研究项目，MPID学生参加并承担研讨会，期刊 俱乐部，研究进展会议，和MPID小型研讨会和讲习班。这一全面 培训准备我们的学生确定重要的研究问题，设计良好的控制， 结合尖端方法的实验，批判性地评估并展示其结果，以及 理解并将伦理原则应用于他们的研究。研究的广度，教学， 领导机会为MPID学生在学术界，工业界和 政府的MPID毕业生在工业界担任高级职务（67%），在学术界担任教职 机构（15%）或政府（6%）。20%的受训人员曾与 MPID培训计划目前正在高排名机构攻读博士后奖学金， 8%继续医学教育。我们的学员已获得NIH F31，F32和R 01资金。给定 培养学生在传染病的广泛领域的重要性，成功的记录， MPID培训计划，以及我们的T32培训人员和培训教师人数的增加 自2002年授予以来，我们一直得到支持，因此我们请求支持增加一个名额。这意味着 在过去10年中供资的职位从1个增加到4个，每年总共有5个空缺。

This application is for the third competing renewal of our interdisciplinary pre-doctoral training program on The Molecular Pathogenesis of Infectious Diseases (MPID) at the University of Colorado Anschutz Medical Campus. Twenty-six faculty with affiliations in six departments offer our trainees opportunities to investigate molecular mechanisms that allow RNA and DNA viruses, Gram-positive and -negative bacteria, Mycobacterium tuberculosis, and protozoan parasites to cause morbidity and mortality in humans worldwide. MPID trainees have access to basic, genomic, computational, translational and systems biology research. Our training faculty have demonstrated productivity for innovative research in infectious diseases, illustrated by the fact that their labs receive an average of $750,000 per year in direct costs. Students are selected for appointment to this training program after they have completed their required coursework, passed their preliminary and comprehensive examinations, and begun their dissertation research. Since the initial award in 2002, the MPID program has funded 49 students, 8% of whom were underrepresented minorities. In the last 5 years, 90% of students affiliated with the MPID Training Program obtained undergraduate degrees from out-of-state institutions. The laboratories of training faculty expanded from 28 graduate students per year with an average of 3.4 publications per student in the previous funding period (2007-2013) to about 35 per year with an average of 4.6 publications per student in the last 4 years. In addition to completing coursework and conducting their mentored research projects, MPID students participate in and assume lead roles in seminars, journal clubs, research-in-progress meetings, and MPID mini-symposia and workshops. This comprehensive training prepares our students to identify important research questions, design well-controlled experiments incorporating cutting-edge approaches, critically evaluate and present their results, and understand and apply principles of ethics to their research. The breadth of the research, didactic, and leadership opportunities prepares MPID students for successful careers in academia, industry, and government. MPID graduates hold senior positions in industry (67%), faculty positions at academic institutions (15%), or government (6%). Twenty percent of trainees who have been affiliated with the MPID Training Program are currently pursuing postdoctoral fellowships in high ranked institutions, and 8% continue their medical education. Our trainees have secured NIH F31, F32, and R01 funding. Given the importance of training students in the broad field of infectious diseases, the successful record of the MPID Training Program, and the increased number of trainees and training faculty that our T32 has supported since it was awarded in 2002, we request support for an additional slot. This represents an increase of one to the four positions funded during the last 10 years, for five total slots per year.