Core 1: Biospecimen and Biomarker Core

Biosecimen和Biomarker Core提供了在Biospecimen科学和 本P01中需要进行分子分析以研究胶质瘤分子亚型的代谢特征 改善患者管理。高质量、注解良好的生物标本，严格和标准化 对肿瘤组织的分析对于检验与科学项目相关的假说是必不可少的。这个 CORE将从手术中获取、注释、分发、跟踪和分析脑肿瘤患者的生物标本 房间。这将包括获取和分析图像制导和多个空间映射样本 来自新诊断和复发的胶质瘤患者。此外，核心将提供组织病理学和 人脑胶质瘤移植瘤的分子分析。本核心的所有方面都按照 指导原则在2016年国家癌症研究所生物信息库指南最佳实践中提出。这个 Biosecimen和Biomarker Core的具体目标如下： 1.获取和保存高质量的生物标本，包括图像引导和空间测绘的组织 来自手术室的样本，以满足科学项目的组织应计要求。 2.进行项目所需的临床相关分子分析。 3.为加工后的组织切片和提取提供神经病理学专业知识 适当的定量和半定量参数。 4.维护与大脑有关的组织库存和相关分子参数数据库 肿瘤中心数据库，集成了成像、临床、分子和病理数据。 5.对核心活动提供一致的监督，以确保严格遵守 关于知情同意和患者保密的规定，以及对 生物检疫剂及其衍生的信息。

The Biospecimen and Biomarker Core provides the leadership and expertise in biospecimen sciences and molecular analyses needed in this P01 to investigate the metabolic signatures of molecular subtypes of glioma to improve patient management. High-quality, well-annotated biospecimens and rigorous and standardized analysis of tumor tissue are essential for testing the hypotheses associated with the scientific Projects. The Core will acquire, annotate, distribute, track, and analyze brain tumor patient biospecimens from the operating room. This will include the acquisition and analysis of image-guided and multiple spatially mapped samples from patients with newly-diagnosed and recurrent glioma. In addition, the Core will provide histopathologic and molecular analysis of human glioma xenografts. All aspects of this Core are performed in accordance with the guiding principles set forth in the 2016 National Cancer Institute Best Practice for Biorepository Guidelines. The specific aims of the Biospecimen and Biomarker Core are as follows: 1. To acquire and preserve high-quality biospecimens, including image-guided and spatially mapped tissue samples, from the operating room to meet the tissue accrual requirements for the scientific projects. 2. To perform the clinically relevant molecular analyses required by the Projects. 3. To provide the neuropathologic expertise for interpretation of the processed tissue sections and extraction of appropriate quantitative and semi-quantitative parameters. 4. To maintain a tissue inventory and database of associated molecular parameters that is linked to the Brain Tumor Center Database, integrating imaging, clinical, molecular, and pathology data. 5. To provide consistent oversight of the Core activities that will ensure the stringent compliance with regulations governing informed consent and patient confidentiality, as well as management of the biospecimens and the information derived from the biospecimens.