Diversity Supplement to the Transitions from Impaired Respiratory Health to Lung Disease

项目总结/摘要 这种多样性补充的目标是促进丹尼尔梅扎博士作为一个独立的医生的发展- 科学家和呼吸流行病学的领导者，重点是一级预防和拦截 慢性阻塞性肺疾病这一多元化补充博士后奖，以支持博士。 Meza将帮助他的职业发展，作为一名专注于了解社会影响的医生调查员。 环境对未来肺部健康和疾病的影响。这将使候选人发展必要的技能 并利用研究结果提交国立卫生研究院（NIH）职业发展（K） 在完成补充之前。这项研究旨在探索呼吸系统健康受损的新风险因素 与母基金及其核心假设一致。候选人和他的导师设计了一个 具体的培训计划，建立在他的背景，内科，肺科和临床 他的目标是开始他作为一名独立调查员的职业生涯。该计划包括开发 在获奖期间通过（1）旨在扩展其知识和培训的课程学习获得额外技能 在临床研究技术方面，（2）与赞助者和合作者组成的多学科团队的互动， 包括肺部和流行病学的研究，以及（3）由国家资助的监督研究项目。 该项目的总体科学目标是确定损害呼吸系统健康的邻近因素 通过两个主要的具体目标：（1）确定是否邻近因素（绿色空间，步行指数， 和接触犯罪/暴力）与呼吸道症状有关， 肺功能超过20-25年的随访和（2）以确定是否邻里因素在年轻 成年后患肺气肿和肺损伤的风险更大。这将是第一个研究 获得并分析青年人冠状动脉疾病风险（CARDIA）的邻里因素 队列。CARDIA队列具有多种优势，包括最初招募的18-30岁的年轻人， 51%的参与者是黑人或非洲裔美国人，并有35年的随访数据。必须 确定肺部健康下降和慢性肺部异常发展的风险因素。我们计划 扩展我们先前的研究邻里剥夺的工作，现在调查特定的邻里 因素及其与呼吸道症状、FEV 1下降和肺发育的关系 疾病我们的提案推进了NHLBI慢性肺一级预防研讨会的目标 通过将邻里因素视为一种新的触发因素，在未来可以进行分析， 未来的慢性肺病

PROJECT SUMMARY/ABSTRACT The goal of this diversity supplement is to facilitate Dr. Daniel Meza's development as an independent physician- scientist and a leader in respiratory epidemiology, with a focus on the primary prevention and interception of chronic obstructive pulmonary disease. This diversity supplement for a post-doctoral award in support of Dr. Meza will aid his career development as a physician-investigator focused on understanding the impact of social environments on future lung health and disease. This will allow the candidate to develop the necessary skills and leverage study findings for the submission of a National Institutes of Health (NIH) career development (K) award prior to completing the supplement. This work exploring novel risk factors for impaired respiratory health is aligned with the parent grant and its central hypotheses. The candidate and his mentors have designed a specific training plan that builds upon his background in internal medicine, pulmonary medicine, and clinical investigation and aims toward launching his career as an independent investigator. This plan includes developing additional skills during the award period through (1) coursework designed to expand his knowledge and training in clinical research techniques, (2) interaction with a multidisciplinary team of sponsors and collaborators, including those in pulmonary and epidemiology, and (3) a supervised research project with national funding. The overall scientific objective of this project is to identify neighborhood factors that impair respiratory health through two primary specific aims: (1) determine whether neighborhood factors (green space, walkability index, and exposure to crime/violence) in young adulthood are associated with respiratory symptoms and decline in lung function over 20-25 years of follow-up and (2) To determine whether neighborhood factors in young adulthood are associated with greater risk of emphysema and lung injury later in life. This will be the first study to obtain and analyze neighborhood factors in the Coronary Artery Disease Risk in Young Adults (CARDIA) cohort. The CARDIA cohort has multiple strengths, including the original enrollment of young adults aged 18-30, 51% of participants identifying as Black or African-American, and having 35 years of follow-up data. It is essential to identify risk factors for decline of lung health and development of chronic lung abnormalities. We plan to expand on our prior work, which examined neighborhood deprivation, to now investigate specific neighborhood factors and their association with developing respiratory symptoms, decline in FEV1, and development of lung disease. Our proposal advances the goal of NHLBI Workshop on the Primary Prevention of Chronic Lung Diseases by looking at neighborhood factors as a novel trigger that in the future can be analyzed to intercept future chronic lung disease.