Microbiome-Balancing Wraps for Managing Eczema

项目摘要/摘要： 该项目的长期目标是开发微生物平衡抗菌包装，用于 特应性皮炎或湿疹感染的治疗。外用类固醇类药物治疗慢性阻塞性肺疾病 特应性皮炎会引起许多副作用和成瘾。此外，用于治疗AD的抗生素 感染消除了皮肤共生菌和目标病原体，导致皮肤微生物 不平衡。皮肤共生在防止重新定植和再定植方面发挥重要作用。 通过抑制病原体来抑制湿疹的发生。由皮肤制成的保护性包裹或湿包裹 共生温和的抗菌化合物可通过促进生长而预防特应性皮炎 对皮肤有益的微生物和抑制皮肤的病原体。CFD研究发现了新的 以天然产品为基础的化合物，具有皮肤共生性，温和的靶向抗菌活性。在这 建议我们寻求开发皮肤微生物-温和的抗菌棉织物，可以释放 复方以一定的速率抑制病原体的同时，促进皮肤共生生长。

Project Summary/Abstract: The long-term goal of this project is to develop microbiome-balancing antimicrobial wraps to use in the treatment of atopic dermatitis or eczema infections. The topical steroids used in the treatment of atopic dermatitis cause many side-effects and addiction. Additionally, the antibiotics used to treat AD infections eliminate skin commensals along with the targeted pathogens, resulting in skin microbial imbalance. Skin commensals play an important role in preventing the re-colonization and re- occurrence of the eczema by inhibiting the pathogens. Protective wraps or wet wraps made of skin commensal gentle antimicrobial compounds can prevent atopic dermatitis by promoting the growth of skin beneficial microbes and inhibiting the skin pathogens. CFD Research has discovered novel natural product-based compounds with skin commensal gentle targeted antimicrobial activity. In this proposal we seek to develop skin microbiome-gentle antimicrobial cotton fabrics that can release the compound at a certain rate to inhibit the pathogens while promoting growth of skin commensals.