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Diversity Supplement: Mechanisms underlying anabolic effects of cyclic compressive loading in muscle

Diversity Supplement: Mechanisms underlying anabolic effects of cyclic compressive loading in muscle
多样性补充:肌肉循环压缩负荷合成代谢效应的机制
批准号:
10320577
负责人:
Timothy Alan Butterfield
金额:
$6.63万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2017
资助国家:
美国
项目状态:
已结题
起止时间:
2017-04-01 至 2023-03-31
关键词:

项目摘要

项目成果

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中文摘要
翻译
摘要 本行政补充文件旨在为Alexander Sklivas(Alex)在 Dupont-Versteegden博士是博士前研究员。它是对PA-21-017:研究附录的回应 促进与健康相关的研究的多样性。亚历克斯将执行在《特定目标3》中提出的实验 并将不仅在科学研究的技术应用方面获得经验, 但也将在写作、陈述和假设开发方面获得熟练的能力。他将进行实验 这将提供关于按摩的交叉效应的知识,我们在所有 按摩模特。他将研究大鼠血清中细胞因子水平的变化 按摩。此外,他还将进行实验,以显示神经系统参与的程度 按摩的交叉效应。他将接受初级导师的这些技巧培训 博士后研究员,高级研究生。他将参加一些课程,如赠款写作和学术课程,以及 除此之外,这为他未来的研究任务做好了准备,他将参加与内容相关的课程,如CELL 生物学和分子生物学。训练计划的主要目标是为亚历克斯的成功做好准备 申请F31级博士后奖学金,为他提供获得 竞争激烈的博士后奖学金。作为健康科学中代表性不足的群体的一员 (西班牙裔)他有能力成为其他学生或博士后研究员的好榜样,就像他一样 已经在他目前参与的方案中参与了多样性、公平和包容性(DEI)领域 承认了。杜邦-弗斯泰登博士将担任亚历克斯的导师,并积极参与学生辅导 以及在天意倡议方面。因此,本副刊将为亚历克斯提供科学背景、写作 并展示技能和学术知识,以成为他所在领域的独立调查员 选择。
英文摘要
Summary This administrative supplement is designed to provide training for Alexander Sklivas (Alex) in the laboratory of Dr. Dupont-Versteegden as a predoctoral fellow. It is in response to PA-21-017: Research Supplement to Promote Diversity in Health-Related Research. Alex will be performing experiments proposed in Specific Aim 3 of the parent RO1 and will be able to gain experience not only in the technical application of scientific inquiry, but will also gain proficiency in writing, presenting and hypothesis development. He will perform experiments that will provide knowledge about the cross over effect of massage that we have observed in all of our massage models. He will investigate the changes in cytokine levels in serum from rats that have undergone massage. In addition, he will perform experiments to show the level of involvement of the nervous system in the cross over effect of massage. He will be trained in these techniques by the primary mentor as well as postdoctoral fellow and senior graduate student. He will take classes, such as grant writing and academia and beyond, that prepare him for future tasks as a researcher and he will take content related classes, such as cell biology and molecular biology. The main goal of the training program is to prepare Alex for a successful application of a F31 predoctoral fellowship which would provide him with the support needed to gain a competitive postdoctoral fellowship. As a member of an underrepresented group in the health sciences (Hispanic) he has the capability to be a good role model for other students or postdoctoral fellows, as he is already involved in the area of diversity, equity and inclusion (DEI) in the program in which he currently is admitted. Dr. Dupont-Versteegden will serve as a mentor for Alex and is heavily involved in student mentoring as well as in DEI initiatives. Therefore, this supplement will provide Alex the scientific background, the writing and presenting skills and the academic knowledge to become an independent investigator in the field of his choice.
期刊论文(14)
专著(0)
科研奖励(0)
会议论文
Mechanotherapy does not Enhance Recovery Following Muscle Disuse Atrophy in Female Rats.
机械疗法不能促进雌性大鼠肌肉废用性萎缩后的恢复。
DOI: --
发表时间: 2022
期刊: FASEB journal : official publication of the Federation of American Societies for Experimental Biology
影响因子: --
作者: [Sklivas,AlexanderB, Rose,Sarah, Abbott,Claire, Miller,Benjamin, Butterfield,Tim, Dupont-Versteegden,Esther]
通讯作者: Dupont-Versteegden,Esther
Age-Related Susceptibility to Muscle Damage Following Mechanotherapy in Rats Recovering From Disuse Atrophy.
从废用性萎缩中恢复的大鼠在机械疗法后对肌肉损伤的年龄相关易感性。
DOI: 10.1093/gerona/glab186
发表时间: 2021
期刊: The journals of gerontology. Series A, Biological sciences and medical sciences
影响因子: --
作者: [Hettinger,ZacharyR, Hamagata,Kyoko, Confides,AmyL, Lawrence,MarcusM, Miller,BenjaminF, Butterfield,TimothyA, Dupont-Versteegden,EstherE]
通讯作者: Dupont-Versteegden,EstherE
DOI: 10.1002/jcsm.12636
发表时间: 2021-03
期刊: Journal of cachexia, sarcopenia and muscle
影响因子: --
作者: [Figueiredo VC, D'Souza RF, Van Pelt DW, Lawrence MM, Zeng N, Markworth JF, Poppitt SD, Miller BF, Mitchell CJ, McCarthy JJ, Dupont-Versteegden EE, Cameron-Smith D]
通讯作者: Cameron-Smith D
Macrophage Regulation of Muscle Regrowth From Disuse in Aging.
巨噬细胞对衰老废用肌肉再生的调节。
DOI: 10.1249/jes.0000000000000201
发表时间: 2019
期刊: Exercise and sport sciences reviews
影响因子: 5.7
作者: [Reidy,PaulT, Dupont-Versteegden,EstherE, Drummond,MicahJ]
通讯作者: Drummond,MicahJ
共 10 条
    Mechanisms underlying local and systemic effects of massage
    • 批准号:
      10055850
    • 项目类别:
    • 资助金额:
      $24.28万
    • 财政年份:
      2020
    • 负责人:
      Timothy Alan Butterfield
    • 依托单位:
    Mechanisms underlying local and systemic effects of massage
    • 批准号:
      10227221
    • 项目类别:
    • 资助金额:
      $19.74万
    • 财政年份:
      2020
    • 负责人:
      Timothy Alan Butterfield
    • 依托单位:
    Mechanisms underlying anabolic effects of cyclic compressive loading in muscle
    • 批准号:
      9900758
    • 项目类别:
    • 资助金额:
      $42.33万
    • 财政年份:
      2017
    • 负责人:
      Timothy Alan Butterfield
    • 依托单位:
    Cyclic compressive loading to negate atrophy and impaired regrowth in aged muscle
    • 批准号:
      8510878
    • 项目类别:
    • 资助金额:
      $22.48万
    • 财政年份:
      2013
    • 负责人:
      Timothy Alan Butterfield
    • 依托单位:
    海外基金