Core 3: Translational Pathology Shared Resource Core

项目总结：翻译病理学共享资源核心 转化病理学共享资源核心（TPSRC）提供协作和收费服务支持 加强范德比尔特-英格拉姆梅哈里医学院（MMC）的基础和转化研究工作 癌症中心（VICC）和田纳西州立大学（大津）研究人员。TPSRC整合了人类 组织采集、组织学/免疫组织化学/组织病理学和形态学核心，位于中心位置 MMC将提供一整套不断扩展的高质量服务，包括人类癌症 研究组织库和分配，人类和动物组织处理，切片，常规和特殊 染色、基于免疫的细胞抗原染色、mRNA和DNA原位定位、组织学和 组织病理学审查和解释，以及各种最先进的成像能力。收集 用于相关研究和分子生物学研究的良好表征的人体组织是 癌症研究，是发展有效的转化医学研究的基础， 个性化的分子诊断和治疗。TPSRC与研究人员合作， 社区和设计，实施和验证新的核心方法和服务。为了促进融合 与生物统计学和生物信息学共享资源核心，MMC提供了一个校园办公室，为内部 为经常使用TPSRC的研究者提供咨询。与巨蟹座的合作 发挥宣传和教育作用的外联核心组织提高了对消除癌症研究工作的认识 非裔美国人和少数民族之间的差距。TPSRC将与人口研究中心密切合作， 和癌症公平临床试验（PRACTICE）共享资源核心，用于生物标本采集。进一步 TPSRC将积极参与由Josiah Ochieng博士提出的MVTCP赞助的研究项目， （项目2）和Anil Shanker博士（试点项目）提供组织和病理学服务，以支持他们的 研究倡议。

PROJECT SUMMARY: TRANSLATIONAL PATHOLOGY SHARED RESOURCE CORE The Translational Pathology Shared Resource Core (TPSRC) provides collaborative and fee-for service support to enhance basic and translational research efforts for Meharry Medical College (MMC), Vanderbilt-Ingram Cancer Center (VICC), and Tennessee State University (TSU) investigators. The TPSRC integrates the Human Tissue Acquisition, Histology/Immunohistochemical/Histopathology, and Morphology Cores, centrally located at MMC to provide a comprehensive suite of continually expanding high-quality services including human cancer research tissue banking and distribution, human and animal tissue processing, sectioning, routine and special staining, immune-based cell antigen staining, mRNA and DNA in-situ localization, histological and histopathological review and interpretation, and a variety of state of the art imaging capabilities. The collection of well-characterized human tissue for correlative research and molecular biology studies is a critical part of cancer research and is the foundation for the development of effective translational medical research and personalized molecular diagnostics and treatment. The TPSRC works collaboratively with the research community and designs, implements, and validates new Core approaches and services. To facilitate integration with the Biostatistics and Bioinformatics Shared Resource Core, MMC provides an on-campus office for in-house consultation purposes for investigators who routinely utilize the TPSRC. Our collaboration with the Cancer Outreach Core in an advocacy and educational role enhances awareness of research efforts to eliminate cancer disparities in African American and minority groups. The TPSRC will work closely with the Population Research And Clinical Trials In Cancer Equity (PRACTICE) Shared Resource Core for biospecimen collection. Further the TPSRC will actively engage with the MVTCP–sponsored research projects proposed by Josiah Ochieng, PhD, (Project 2) and Anil Shanker, PhD, (Pilot Project) to provide tissues and pathology services to support their research initiatives.