Neurobehavioral Evaluation Core

摘要 神经行为评估核心(NEC)的使命是为哥伦比亚特区提供智力和 发展障碍研究中心(DC-IDDRC)研究人员与潜在资源相联系 神经发育障碍的生物学机制与行为和认知结果的测量 在人类和动物模型中。DC-IDDRC调查人员可以访问最先进的神经行为 人类和相关动物模型的评估工具，用于将临床前和临床研究与 IDDS相关异常的遗传和神经生物学分析。NEC通过以下方式提高效率 提供个别实验室或调查人员无法接触到的专家人员和测试工具。这个 NEC由两个互补的子核组成；人类神经行为核心(HNEC)，由 麦迪逊·贝尔博士和动物神经行为核心(ANEC)由约书亚·科尔宾博士执导。初级阶段 国家执行委员会的目标是：(A)全面展望、规划、培训和执行人权 人类同源动物模型中的行为任务和互补性行为评估 神经发育障碍，(B)开发、维护和实施最先进的平台和资源 用于人类和动物神经行为研究以及跨多个动物模型，(C)合作和 集成所有DC-IDDRC核心，解开从基因到电路再到行为的神经生物学机制 (D)促进开展健壮、可重复和严谨的科学研究 对神经科学和IDDS领域有很大影响的调查，(E)将研究结果广泛传播到 科学界和学术界通过出版物、演讲和国际会议论坛， (F)利用从人类和动物行为评估中获得的知识来测试和翻译调查结果 从长凳到床边。这些目标将通过以下具体目标实现：(1)界定 IDDS对人类神经行为和动物行为相关性的影响，(2)扩展和 实施使用最先进的技术进行人和动物行为评估；以及(3) 开发/确定对人类IDDS变化敏感的纵向评估范例 和动物模型，这将是监测干预研究成功的关键。NEC已经 在分析人类和动物模型中的一些神经发育方面的长期优势 这些疾病包括自闭症谱系障碍、癫痫、胎儿酒精综合征和胎儿/新生儿脑损伤。 在过去的几年里，我们非常成功的动物模型研究已经阐明了细胞和分子 在这些流行的情况下，生理和行为异常的潜在机制，而我们的 人类研究已经将大脑发育的非典型轨迹与其结构和行为联系起来 相互关联。在这些优势的基础上，我们日益多样化和复杂的人类和动物行为 评估平台也将广泛适用于一系列神经发育疾病。

Abstract The mission of the Neurobehavioral Evaluation Core (NEC) is to provide District of Columbia Intellectual and Developmental Disabilities Research Center (DC-IDDRC) investigators with resources to link underlying biological mechanisms of neurodevelopmental disorders with behavioral and cognitive outcomes as measured in humans and animal models. DC-IDDRC investigators have access to state-of-the-art neurobehavioral assessment tools in humans and cognate animal models to integrate preclinical and clinical studies with genetic and neurobiological analysis of abnormalities associated with IDDs. The NEC enhances efficiency by providing access to expert personnel and testing tools not available to individual labs or investigators. The NEC is comprised of two complementary subcores; the Human Neurobehavior Core (HNEC), directed by Madison Berl, PhD and the Animal Neurobehavior Core (ANEC) directed by Joshua Corbin, PhD. The primary objectives of the NEC are to provide: (a) overall vision, planning, training and implementation of human behavioral tasks and complementary behavioral assessments in cognate animal models of human neurodevelopmental disorders, (b) to develop, maintain and implement state of the art platforms and resources for human and animal neurobehavior investigation and across multiple animal models, (c) to collaborate and integrate with all DC-IDDRC cores to unravel neurobiological mechanisms from genes to circuits to behaviors underlying a host of IDDs, (d) to facilitate the conduct of robust, reproducible and rigorous scientific investigation with a high impact on the field of neuroscience and IDDs, (e) to disseminate findings broadly to the scientific and academic communities via publications, presentations and international conference forums, (f) to use the knowledge gained from human and animal behavior assessments to test and translate findings from the bench to the bedside. These goals will be achieved in the following specific aims: (1) To define the consequences of IDDs on human neurobehavior and animal behavioral correlates, (2) To expand and implement the use state-of-the-art technologies for human and animal behavior assessment and (3) To develop/identify longitudinal assessment paradigms that are sensitive to change in IDDs in humans and animal models and that will be critical for monitoring success of intervention studies. The NEC has long standing strengths in the analysis of humans and animal models of a number of neurodevelopmental disorders including autism spectrum disorders, epilepsy, fetal alcohol syndrome and fetal/neonatal brain injury. Over the past years, our highly successful animal model studies have elucidated cellular and molecular mechanisms underlying physiological and behavioral abnormalities in these prevalent conditions, while our human investigation has linked atypical trajectories of brain development to their structural and behavioral correlates. Building on these strengths, our increasing variety and sophisticated human and animal behavioral assessment platforms will also be widely applicable across a host of neurodevelopmental conditions.