Multimodal Neuroimaging Predictors of Non-Suicidal Self-Injury in the ABCD Study

项目总结摘要 非自杀性自我伤害(NSSI)，即故意破坏自己的身体组织而没有自杀意图，是 这在青少年中非常普遍，也是自杀未遂和死亡的危险因素。NSSI通常会出现 在青春期，当支持自我调节的大脑网络，如认知控制网络， 仍处于成熟期，因此大脑网络功能障碍可能是青少年NSSI风险的基础。这个项目将 利用青少年大脑认知发展(ABCD)研究的数据，包括基线MRI数据 在9-10岁的青年时期收集，以识别发育中的青年的大脑网络异常 NSSI在两年或更长时间后。我们的分析将在多模式磁共振数据上进行，并集中在两个 主要的内在功能大脑网络。这些都是显著网络，涉及到情感，并牵涉其中 在以前对NSSI和认知控制网络的研究中，NSSI和认知控制网络对情绪调节很重要，但很少 在国家社科院全面学习。我们的中心假设是，患有NSSI的年轻人增强了 显著网络的活跃性和完整性以及认知控制的活动性和完整性降低 将网络与没有NSSI的单独匹配的对照样本进行比较。我们提出了一种横截面 对首次发生NSSI(且无NSSI病史)的年轻人进行基线MRI数据分析 自杀念头或企图)在第二年或之后。在第二年，N=141(68名男性)青年符合我们的NSSI标准。 男性的数量意味着这将是第一次有足够的男性来分析性的神经成像研究 不同之处。根据社区流行率，我们保守地估计，560名青年将达到我们的NSSI 按第6年(R01第3年)的分组纳入标准，总样本量为1120。AIM 1将研究fMRI 测量显著网络(情绪N-back任务)和认知控制网络(停顿)的任务 信令任务)功能。我们还将研究这些网络在不同任务条件下的连通性 心理生理交互作用分析。目标2将调查凸起的结构完整性和 通过分析扩散成像来研究白质的认知控制网络，以及T1加权磁共振成像来研究 测量皮质厚度和杏仁核形状和体积。目标3将调查潜在的修改 父母抑郁史和学校环境因素对抑郁相关关系的影响 脑结构和功能，以及NSSI风险。探索性的子目标将确定较早的发病年龄 NSSI的风险与更强的网络效应有关。通过研究大脑网络 NSSI开始，这项研究有望识别可用于实验的生物靶点 治疗学治疗的发展，如药物或神经调节疗法。这些 可以减少NSSI对个人及其亲人的有害身体和心理影响，以及 防止未来因自杀而死亡。

PROJECT SUMMARY ABSTRACT Non-suicidal self-injury (NSSI), the deliberate destruction of one’s own body tissue without suicidal intent, is alarmingly common in adolescents, and a risk factor for suicide attempts and deaths. NSSI typically emerges in adolescence, when brain networks supporting self-regulation, such as the cognitive control network, are still maturing, thus dysfunctional brain networks may underlie NSSI risk in adolescents. This project will leverage data from the Adolescent Brain Cognitive Development (ABCD) Study, including baseline MRI data collected when youth are aged 9-10 years, to identify brain network abnormalities in youth who develop NSSI two or more years later. Our analyses will be performed on multimodal MRI data and focus on two major intrinsic functional brain networks. These are the salience network, involved in emotion, and implicated in previous studies of NSSI, and the cognitive control network, important for emotion regulation, yet less comprehensively studied in NSSI. Our central hypothesis is that youth who develop NSSI have enhanced activity and integrity of the salience network and reduced activity and integrity of the cognitive control network compared to a sample of individually matched controls without NSSI. We propose a cross-sectional analysis of MRI data from baseline, in youth who develop NSSI for the first time (and with no history of suicidal ideation or attempt) at year 2 or later. At Year 2, N=141 (68 males) youths met our NSSI criteria. The number of males means this will be the first neuroimaging study with sufficient males to analyze sex differences. Based on community prevalence, we conservatively estimate that 560 youth will meet our NSSI group inclusion criteria by Year 6 (R01 Year 3), for a total sample size of 1120. Aim 1 will investigate fMRI tasks that measure salience network (an emotional N-back task) and cognitive control network (a Stop Signal task) function. We will also study connectivity of these networks during different task conditions using psychophysiological interaction analysis. Aim 2 will investigate the structural integrity of the salience and cognitive control networks by analyzing diffusion imaging to study white matter, and T1-weighted MRI to measure cortical thickness and amygdala shape and volume. Aim 3 will investigate the potential modifying influence of parental history of depression and of school environmental factors on the relationship between brain structure and function, and NSSI risk. An exploratory sub-aim will identify whether earlier age of onset of NSSI is associated with stronger network effects on risk for NSSI. By studying brain networks prior to NSSI onset, this study has promise for identifying biological targets that could be used in experimental therapeutics treatment development, such as pharmacological or neuromodulatory therapeutics. These could reduce the harmful physical and psychological effects of NSSI on individuals and their loved ones, and prevent future deaths by suicide.