Main Administrative Core

ASPREE-XT BI-国家行政核心-摘要/摘要 阿司匹林在减少老年事件中的作用(ASPREE)研究成功地在美国和澳大利亚建立了一组19,114名健康的老年人，他们在基线水平上没有阿尔茨海默病和相关痴呆(ADRD)、心血管疾病和严重的身体残疾，并测试了接触低剂量阿司匹林(LDA)是否会延长无痴呆症和无残疾生存时间。尽管干预期已经结束，但这一庞大而多样化的队列的建立，加上干预期取得的前所未有的发现，创造了一个难得的机会，可以继续监测重要的健康结果和危及老龄化人口，特别是ADRD和癌症的无残疾生存的前因。将每年从参与者那里收集个人健康信息，重大临床事件将通过为ADRD(以及阿尔茨海默病和非ADRD的亚型分类)、癌症(事件、转移、类型、阶段和死亡)以及包括死亡在内的其他关键健康后果的专家裁决而准备的病例文件来确认。对ASPREE等大型长期老龄化研究的观察性跟踪得益于ADRD专业知识的连续性、经验和领导力。在这份资金申请中，ASPREE领导团队建议将美国和澳大利亚参与者的随访时间再延长五年(即“ASPREE-XT”)，这将极大地丰富一项已经独一无二且极具价值的国际研究资产，该资产专注于延长老年人健康的独立生活，远离痴呆症和残疾。实现这一目标所需的基础设施将依赖于美国和澳大利亚协调中心的连续性、领导力和经验，这些中心已经通过模范的研究进行和完成证明了它们在ASPREE试验中的成功。这包括两个国家的标准化培训和认证，以确保对年度认知电池和触发的痴呆症评估的一致管理，其中包括阿尔茨海默病评估量表认知分量表。两国行政核心将部署必要的基础设施和治理，以实现ASPREE-XT纵向队列研究的目标，包括了解低剂量阿司匹林对认知功能减退、ADRD、残疾和癌症预防的遗留影响。两国行政核心的总体目标是促进来自所有核心的信息、思想和数据的动态交换，以洞察可能延长老年人无痴呆症和无残疾生存的因素。

ASPREE-XT BI-NATIONAL ADMINISTRATIVE CORE – SUMMARY / ABSTRACT The ASPirin in Reducing Events in the Elderly (ASPREE) study successfully established a cohort of 19,114 healthy older adults in the U.S. and Australia who were free of Alzheimer’s disease and related dementias (ADRD), cardiovascular disease, and significant physical disability at baseline, and tested whether the exposure to 5 years of low-dose aspirin (LDA) would prolong dementia-free and disability-free survival. Although the intervention period has ended, the establishment of this large and diverse cohort, coupled with unprecedented findings from the intervention period, has created a rare opportunity for continued surveillance of important health outcomes and the antecedents that jeopardize disability-free survival in this aging population; especially ADRD and cancer. Personal health information will be collected annually from participants, and major clinical events will be confirmed through case documentation prepared for expert adjudication of ADRD (and sub-type classification into Alzheimer’s disease and non- ADRD), cancer (incident, metastatic, type, stage and death), and other key health outcomes including death. Observational follow-up of large, long-term aging studies such as ASPREE benefit from continuity, experience and leadership with ADRD expertise. In this funding request, the ASPREE leadership team proposes to extend follow-up of the participants in both the U.S. and Australia for an additional five years (i.e., ‘ASPREE-XT’), which will greatly enrich an already unique, and highly valuable international research asset focused on prolonging healthy independent life in the elderly, free of dementia and disability. The infrastructure needed to accomplish this will rely on the continuity, leadership, and experience of the U.S. and Australian Coordinating Centers that have proven their success in the ASPREE trial through the exemplary study conduct and completion. This includes bi-national standardized training and accreditation to ensure the consistent administration of the annual cognitive battery and triggered dementia assessments which include the Alzheimer's Disease Assessment Scale cognitive subscale. The Bi-National Administrative Core will deploy the infrastructure and governance necessary to accomplish the aims of the ASPREE-XT longitudinal cohort study, including to understand the legacy effects of low dose aspirin on cognitive decline, ADRD, disability and cancer prevention. The overarching goal of the Bi-National Administrative Core is to foster the dynamic exchange of information, ideas, and data arising from all Cores to provide insight into factors that may extend dementia-free and disability-free survival of older adults.