Pilot Research Projects Core

试点研究项目核心（PRPC）的作用是监督和帮助开发试点项目， 耶鲁大学/NIDA神经蛋白质组学中心的新研究人员，有助于鼓励我们的年轻研究人员 中心的实验室开始从事药物滥用研究，传播中心的核心 研究成瘾的神经生物学的研究人员尚未使用神经蛋白质组学 技术，并扩大该中心的技术能力。该中心大大增加了 研究人员使用蛋白质组学方法在耶鲁大学和其他7个机构，并已成为国家资源， 药物成瘾生物学方面的蛋白质组学研究。在11-14赠款年授予的19个项目有 已经导致至少9篇出版物，4篇摘要，13项赠款和1项待批准的赠款申请。此外，本发明还提供了一种方法， 其中5名获奖者已经获得了独立的职位，他们使用蛋白质组学 接近。15年的4个奖项将扩大中心的技术，并将产生新颖的 与成瘾和大脑功能相关的发现。在目标1中，我们将在这一成功的基础上， 通过我们的网站，Twitter，电子邮件，EAB和NIDA计划官员提出建议。PRPC将鼓励 建议应用Cores提供的技术或开发新技术的应用。 申请将接受来自中心和非中心研究人员的药物滥用专家， 对神经蛋白质组学研究感兴趣的人，以及具有细胞和 神经元信号传导的分子方面，对启动神经蛋白质组学研究的兴趣， 虐待申请将接受研究生，博士后研究员和更高水平的研究 这些研究人员的实验室。在目前的提案中，我们包括了4个潜在项目， 其中包括一项技术开发试点项目，该项目将与其他8项提案一起提交给 竞争性审查，如果这种更新得到资助。在目标2中，我们将继续由两个 耶鲁大学的高级研究人员，包括试点项目核心主任，以及两名非耶鲁大学的评审员， 他们当中没有人与所审议的建议有利益冲突。使用与成功飞行员相似的标准， 提交的建议书将根据它们是否符合该计划的核心使命进行评估， 以及它们的整体科学价值。在目标3中，我们将评估和跟踪试点计划的成功， 通过分析出版物、演讲和赠款申请。在目标4中，每个获资助的项目将 由中心核心人员指导，该人员是所用技术的专家，并将提供培训， 获奖者。此外，如果获奖者来自没有药物滥用经验的实验室， 研究，他们将被分配一名在药物滥用研究方面经验丰富的中心研究员， 将在适当的药物滥用模型和实验设计方面提供指导。

The role of the Pilot Research Project Core (PRPC) will be to oversee and help develop pilot projects that bring new investigators into the Yale/NIDA Neuroproteomics Center, help encourage young investigators in our Center's laboratories embark on careers in substance abuse research, disseminate the Center's core technologies to researchers investigating the neurobiology of addiction who are not yet using neuroproteomics technologies, and expand the technical abilities of the Center. The Center has greatly increased the pool of researchers using proteomic methods at Yale and 7 other institutions, and has become a national resource for proteomic studies of biological aspects of drug addiction. The 19 projects awarded in grant years 11-14 have already resulted in at least 9 publications, 4 abstracts, 13 grants and one pending grant application. In addition, 5 of these awardees already have gone on to independent positions where they are using proteomic approaches. The 4 awards in year 15 will expand the Center's technologies and also will result in novel findings relevant to addiction and brain function. In Aim 1, we will build on this success and solicit new pilot proposals via our web site, Twitter, emails, EAB, and NIDA program officials. The PRPC will encourage applications that propose to apply technologies available from the Cores or to develop new technologies. Applications will be accepted from Center and non-Center investigators expert in substance abuse with interests in initiating research in neuroproteomics, and non-Center investigators with expertise in cell and molecular aspects of neuronal signaling with interests in initiating neuroproteomics research on substance abuse. Applications will be accepted from graduate students, postdoctoral fellows and higher level research staff from these investigators' laboratories. In the current proposal, we have included 4 potential projects, including one Technology Development Pilot, which together with 8 other proposals would be submitted for competitive review if this renewal is funded. In Aim 2, we will continue to have pilot projects reviewed by two senior Yale investigators, including the Director of the Pilot Project Core, as well as two non-Yale reviewers, none of whom have a conflict of interest with the proposals reviewed. Using similar criteria to successful pilots, the submitted proposals will be evaluated based on whether they meet the core mission of the program, as well as on their overall scientific merit. In Aim 3, we will evaluate and track the success of the Pilot Program, through analysis of publications, presentations and grant applications. In Aim 4, each funded project will be mentored by a Center Core staff who is an expert in the technology to be used and who will provide training to the awardee. Further, if the awardee is from a laboratory that does not have experience in drug abuse research, they will be assigned a Center investigator who is highly experienced in drug abuse research who will provide guidance in appropriate models of substance abuse and in experimental design.