Cellular and Molecular Mechanisms of Immune Inflammatory Reactions

项目摘要/摘要 这项培训补助金现已进入第36个年头，为一项独特的 约翰霍普金斯大学免疫学跨学科和跨部门博士前培训计划 大学医学院免疫学研究生课程(GPI)。GPI的使命是 为学生提供有关免疫生物学的细胞、生物化学和遗传学方面的培训 回应。我们为学员提供识别免疫学中重要研究问题的能力，找到 解决这些问题，广泛和创造性地思考生物问题，并交流想法 有效地传递给其他人。来自10个不同系的36名教职员工参加了 计划并为学员提供广泛的培训机会。专业知识和调查领域 包括癌症免疫学、自身免疫学、传染病免疫学、微生物组相关免疫学 过敏和哮喘，免疫细胞信号转导，免疫细胞基因表达和调节， 发展和维持免疫细胞和组织，抗原处理，呈递和识别， 免疫反应工程、高通量和全基因组免疫评估， 免疫缺陷和移植免疫学。在这些领域，培训环境通过以下方式得到改善 基础科学和/或临床医学相关领域的机构实力。不同品种间的杂交受精 基础研究和临床疾病研究是培训环境的一个重要方面。在第一次 今年，学生们要参加一门严格的课程，其中包括基础免疫学课程，研究生 免疫学、大分子结构与分析、遗传学、分子生物学与基因组学， 生物信息学，细胞结构和动力学，途径和调节，负责任的研究行为，以及 此外，还进行了三次实验室旋转。第一年还需要为期一年的免疫学核心 讨论课程和免疫学研究导论课程。第一年结束时，实习生 选择他们的论文导师和实验室。第二年的培训包括各种选修课， 一次全面的口试，以及第一次论文委员会会议。专业发展和 职业规划是该项目不可或缺的一部分。大多数学生发表了几篇研究论文，原因是 他们的论文研究。培训结束时举办了一次公开研讨会，并提交了 博士论文。在整个教学和研究过程中，学员的进展受到密切监测 通过多种机制。一项广泛而成功的招收少数族裔学生的计划 实施。预计将有7个博士前职位，并计划任命每名实习生进入 为期两年的培训补助金。

PROJECT SUMMARY/ABSTRACT This Training Grant, now entering its 36th year, provides the core source of support for a unique interdisciplinary and interdepartmental pre-doctoral training program in Immunology at The Johns Hopkins University School of Medicine, the Graduate Program in Immunology (GPI). The mission of the GPI is to provide students with training in cellular, biochemical, and genetic approaches to the biology of the immune response. We provide trainees with the ability to identify significant research questions in immunology, find solutions to these questions, think broadly and creatively about biological problems, and communicate ideas effectively to others. There are 36 faculty members from 10 different departments who participate in the program and provide a broad range of training opportunities for trainees. Areas of expertise and investigation include cancer immunology, autoimmunity, immunology of infectious disease, microbiome-related immunology, allergy and asthma, immune cell signal transduction, immune cell gene expression and regulation, development and maintenance of immune cells and tissues, antigen processing, presentation and recognition, engineering of immune responses, high throughput and genome-wide assessment of immunity, immunodeficiency, and immunology of transplantation. In these areas, the training environment is enhanced by institutional strength in relevant areas of basic science and/or clinical medicine. Cross-fertilization between basic research and clinical disease studies is an important aspect of the training environment. During the first year, students take a rigorous curriculum that includes courses in fundamental immunology, graduate immunology, macromolecular structure and analysis, genetics, molecular biology and genomics, bioinformatics, cell structure and dynamics, pathways and regulation, responsible conduct of research, and in addition undertake three laboratory rotations. The first year also entails a year-long immunology core discussion course, and an introduction to immunology research course. At the end of the first year, trainees select their thesis mentors and laboratories. The second year of training features a variety of elective courses, a comprehensive qualifying oral exam, and the first thesis committee meeting. Professional development and career planning is an integral part of the program. Most students publish several research papers as a result of their thesis research. Training concludes with the presentation of a public seminar and submission of the doctoral thesis. Progress of trainees throughout the didactic and research progress is monitored closely through multiple mechanisms. An extensive and successful program for recruiting minority students has been implemented. Seven predoctoral positions are projected with planned appointment of each trainee to the training grant for two years.