Cellular and Molecular Mechanisms of Immune Inflammatory Reactions

项目总结/摘要 这项培训补助金现已进入第36个年头，为一个独特的 约翰霍普金斯免疫学跨学科和跨部门的博士前培训计划 大学医学院，免疫学研究生课程（GPI）。GPI的使命是 为学生提供免疫生物学的细胞，生物化学和遗传方法的培训。 反应我们为学员提供识别免疫学中重要研究问题的能力， 这些问题的解决方案，广泛和创造性地思考生物学问题，并交流想法 有效地对他人。有来自10个不同部门的36名教师参加了 为受训人员规划和提供广泛的培训机会。专门知识和调查领域 包括癌症免疫学、自身免疫、传染病免疫学、微生物组相关免疫学 过敏和哮喘，免疫细胞信号转导，免疫细胞基因表达和调控， 免疫细胞和组织的发育和维持，抗原加工、呈递和识别， 免疫应答的工程化，免疫的高通量和全基因组评估， 免疫缺陷和移植免疫学。在这些领域，培训环境得到了改善， 基础科学和/或临床医学相关领域的机构实力。异花受精 基础研究和临床疾病研究是训练环境的一个重要方面。在第一 一年，学生参加严格的课程，包括基础免疫学课程，研究生 免疫学、大分子结构和分析、遗传学、分子生物学和基因组学， 生物信息学，细胞结构和动力学，途径和调节，负责任的研究行为，以及 此外，还进行了三次实验室轮换。第一年还需要为期一年的免疫学核心 讨论课程和免疫学研究课程介绍。在第一年结束时，学员 选择论文导师和实验室。第二年的培训包括各种选修课程， 综合资格口试，以及第一次论文委员会会议。专业发展和 职业规划是该计划的一个组成部分。大多数学生发表了几篇研究论文， 他们的论文研究。培训结束时，将举行一次公开研讨会， 博士论文学员在整个教学和研究过程中的进展受到密切监测 通过多种机制。一个广泛而成功的招收少数民族学生的计划， 切实贯彻预计将有七个博士前职位，并计划任命每一位实习生到 两年的培训补助金。

PROJECT SUMMARY/ABSTRACT This Training Grant, now entering its 36th year, provides the core source of support for a unique interdisciplinary and interdepartmental pre-doctoral training program in Immunology at The Johns Hopkins University School of Medicine, the Graduate Program in Immunology (GPI). The mission of the GPI is to provide students with training in cellular, biochemical, and genetic approaches to the biology of the immune response. We provide trainees with the ability to identify significant research questions in immunology, find solutions to these questions, think broadly and creatively about biological problems, and communicate ideas effectively to others. There are 36 faculty members from 10 different departments who participate in the program and provide a broad range of training opportunities for trainees. Areas of expertise and investigation include cancer immunology, autoimmunity, immunology of infectious disease, microbiome-related immunology, allergy and asthma, immune cell signal transduction, immune cell gene expression and regulation, development and maintenance of immune cells and tissues, antigen processing, presentation and recognition, engineering of immune responses, high throughput and genome-wide assessment of immunity, immunodeficiency, and immunology of transplantation. In these areas, the training environment is enhanced by institutional strength in relevant areas of basic science and/or clinical medicine. Cross-fertilization between basic research and clinical disease studies is an important aspect of the training environment. During the first year, students take a rigorous curriculum that includes courses in fundamental immunology, graduate immunology, macromolecular structure and analysis, genetics, molecular biology and genomics, bioinformatics, cell structure and dynamics, pathways and regulation, responsible conduct of research, and in addition undertake three laboratory rotations. The first year also entails a year-long immunology core discussion course, and an introduction to immunology research course. At the end of the first year, trainees select their thesis mentors and laboratories. The second year of training features a variety of elective courses, a comprehensive qualifying oral exam, and the first thesis committee meeting. Professional development and career planning is an integral part of the program. Most students publish several research papers as a result of their thesis research. Training concludes with the presentation of a public seminar and submission of the doctoral thesis. Progress of trainees throughout the didactic and research progress is monitored closely through multiple mechanisms. An extensive and successful program for recruiting minority students has been implemented. Seven predoctoral positions are projected with planned appointment of each trainee to the training grant for two years.