Synthetic Chemical Biology Core

项目摘要 虽然“化学生物学”的精确定义可能是一个热烈讨论的主题，但它是 普遍理解为需要使用小分子和肽来更好地理解 生物学根据其特定从业者的目标，在药物中发现的特定化合物 化学生物学程序的背景是最常见的体外或体内药理学工具， 阐明特定途径。然而，在某些情况下，这种“探测器”的发展 通过为临床前研究提供先导化合物，构成了药物发现的第一步。在 无论哪种情况，一个特定的化学生物学项目的成功需要确定合适的 分子的研究，以牺牲不需要的性能为代价优化所需的性能， 定制探针的构建，用于额外的生物学评价。因为很少有理想 一个探针分子正处于一个筛选集合中，等待被发现，所有上述活动 依靠合成药物化学来优化初始命中，并最终提供周围的分子 一个化学生物学课程的基础。核心D，合成化学生物学，将使 研究人员通过提供肽的设计和合成来了解和对抗传染病 以及化学上针对特定生物需求的小分子。

Project Summary Although the precise definition of “chemical biology” can be a subject for lively discussion, it is universally understood to entail the use of small molecules and peptides for greater understanding of biology. Depending on the goals of its specific practitioners, the specific compounds discovered in the context of a chemical biology program are most often pharmacological tools for in vitro or in vivo elucidation of particular pathways. In some cases, however, the development of such “probes” constitutes the first step toward drug discovery by providing lead compounds for preclinical study. In either case, the success of a given chemical biology project requires the identification of suitable molecules for study, the optimization of desired properties at the expense of undesired properties, and the construction of custom-made probes for additional biological evaluation. Since it is rare that an ideal probe molecule is sitting in a screening collection just waiting to be discovered, all of the above activities rely on synthetic medicinal chemistry to optimize initial hits and ultimately provide the molecule around which a chemical biology program will be based. The Core D, Synthetic Chemical Biology, will enable researchers to understand and combat infectious disease by providing design and synthesis of peptides and small molecules that are chemically targeted to the specific biological needs.