Building Research Capacity to Study Periodontitis and Associated Systemic Comorbidities in the Caribbean

项目摘要 西印度群岛大学莫纳校区的医学科学系旨在扩大其跨- 通过制定培训计划来研究牙周炎的决定因素， 在牙买加，非传染性慢性疾病。这个项目是为了满足 牙周炎是一种高度流行的非传染性慢性疾病， 和全身健康，这方面的流行病学和病理生理学知识缺乏 在加勒比地区。该计划将侧重于扩大临床，流行病学和基础科学 基础医学科学系和莫纳牙科学院合作的研究能力 加勒比健康研究所（CAIHR）发展这种研究能力需要 临床和基础科学家的培训将由西印度群岛大学的教师指导， 与布法罗大学和美国拉什大学合作。学员将获得学位 在西印度群岛大学就读硕士或博士课程和牙科临床医生进行后， 博士奖学金培训，谁将是跨学科团队的一部分，将调查社会，行为， 牙买加受试者队列中牙周炎的微生物组和宿主反应决定因素。的具体目标 该申请是为了1）创建一个年轻的研究人员核心（4名博士前基础科学家或流行病学家 和4名博士后牙医科学家）进行牙周病的跨学科研究， 牙买加的相关合并症。2)提供多学科团队指导方法， 创新研究，整合流行病学，微生物组科学，免疫学，转化医学和 数据科学3)为在西印度群岛大学建立大型人类受试者队列奠定基础 研究牙周病和相关的合并症，从而支持未来的独立研究 青年教师的活动将培养下一代研究生和研究员。这些目标 将通过由导师和受训人员组成的跨学科小组来完成， 牙周炎在儿童/青少年队列和受以下因素影响的成人队列中的病理生理学 心脏代谢系统性疾病根据每个学员的个性化发展定制课程 计划将得到实施。学员将在美国实验室进行短期（6个月）培训 由在流行病学，牙周病学，微生物组， 生物信息学，免疫学和心脏代谢疾病，同时完成研究学位或博士后 西印度群岛大学的课程。该计划预计将提供严格的跨学科 科学的培训经验，并创造一个有潜力的候选人加入大学的教师库 西印度群岛该方案还将满足牙买加口腔健康研究和干预的需要。

PROJECT SUMMARY The Faculty of Medical Sciences at the University of the West Indies Mona Campus aims to expand its inter- disciplinary research capacity by developing a training program to study the determinants of periodontitis and associated non-communicable chronic diseases in Jamaica. This program was created in response to the need for research in periodontitis, a highly prevalent non-communicable chronic condition with implications for oral and systemic health, for which there is lack of knowledge with respect to its epidemiology and pathophysiology in the Caribbean region. This program will be focused on expanding the clinical, epidemiology and basic science research capacity at the Department of Basic Medical Sciences and the Mona School of Dentistry in collaboration with The Caribbean Institute for Health Research (CAIHR). The development of this research capacity requires the training of clinical and basic scientists to be mentored by faculty from the University of the West Indies in collaboration with The University at Buffalo and Rush University in the US. Trainees will be degree candidates at the University of the West Indies enrolled in Masters or PhD programs and dental clinicians conducting post- doctoral fellowship training, who will be part of inter-disciplinary teams that will investigate the social, behavioral, microbiome and host response determinants of periodontitis in Jamaican subject cohorts. The specific aims of this application are to 1) Create a core of young investigators (4 pre-doctoral basic scientists or epidemiologists and 4 post-doctoral dentist-scientists) to conduct inter-disciplinary research in periodontal disease and associated comorbidities in Jamaica. 2) Provide a multidisciplinary team-based mentoring approach to conduct innovative research that integrates epidemiology, microbiome science, immunology, translational medicine and data science. 3) Build the foundation to establish large human subject cohorts at the University of the West Indies to study periodontal disease and associated comorbidities, thereby supporting future independent research activities of young faculty who will train the next generation of graduate students and fellows. These objectives will be accomplished through inter-disciplinary teams of mentors and trainees focused on evaluating the pathophysiology of periodontitis in a cohort of children/adolescents and in an adult cohort affected by cardiometabolic systemic disease. Customized curricula based on each trainee’s individualized development plan will be implemented. Trainees will have a short-term (6 months) training experience in US laboratories directed by faculty mentors with extensive experience in epidemiology, periodontology, microbiome, bioinformatics, immunology and cardiometabolic disease, while completing their research degree or postdoctoral programs at the University of the West Indies. This program is expected to provide a rigorous interdisciplinary scientific training experience and create a pool of candidates with potential to join the Faculty at the University of the West Indies. This program will also address a need for oral health research and interventions in Jamaica.