Collaborative Pediatric Critical Care Research Network - Clinical Site

项目摘要/摘要-明尼苏达大学 协作性儿科重症监护研究网络(CPCCRN)在建立 儿科危重病医学知识库。这一选址方案的总体目标是为加州大学 明尼苏达州共济会儿童医院(UMMCH)，在现场首席调查员玛丽的领导下 Steiner，医学博士，MS，加入CPCCRN的这一扩展迭代。UMMCH是一个独立的第四级护理机构， 学术儿童医院位于明尼苏达州明尼阿波利斯市，为不同领域的儿童和家庭提供服务 种族、民族和社会经济背景。它有24张病床，内科/外科和心内科 重症监护病房，提供全方位的儿科和外科专科服务。UMMCH有一个 拥有雄厚的临床研究和创新历史，并拥有密歇根大学的资源 明尼苏达州，该州的土地赠与大学。儿科重症监护研究包括许多已完成的和 正在进行的研究由多个教职员工支持，包括这项拨款的联合调查员。随着不断增加 来自内部和外部赠款的支持以及儿科设备创新中心的发展， 2019年，该科在开展新研究方面排名第三，仅次于血液学/肿瘤学和 HSCT。儿童明尼苏达(儿童)将在阿尔贝托的领导下作为我们的辅助站点 马里兰州金莺。儿童医院是一家非营利性的独立儿童医院，也位于明尼阿波利斯，拥有 长期参与重症护理研究，包括CPCCRN的几项研究。一起， UMMCH和儿童医院将提供55个儿科ICU床位和超过3500个年度入院人数，这些 捕获整个上中西部的大多数危重儿童，并将促进参与 大型临床试验。“脓毒症多脏器个体化免疫调节”的建议 功能障碍综合征(MODS)“试验解决了免疫抑制儿童将受益的假说 粒细胞-巨噬细胞集落刺激因子和儿童 高度炎症将受益于有针对性的抗炎治疗。效益将根据以下方面进行评估 从MODS中恢复，以及与健康相关的短期和长期生活质量措施。这种伙伴关系 有成功完成这项试验的知识和技能，包括样品采集和处理 免疫表型和收集短期和长期结果。施泰纳博士和金莺 支持各自的机构参与CPCCRN，并优先招募患者和 对它的研究产生了收益。这些机构坚定地致力于与CPCCRN网站和数据的合作 协调中心进行的建议和未来的研究。我们的临床中心和辅助站点将 为我们才华横溢的年轻教员提供当地指导，并将支持他们参与中央 所需CPCCRN网络B.3部分中描述的CPCCRN指导活动 组织结构附加到此PL1应用程序的整体组件。

PROJECT SUMMARY/ABSTRACT – University of Minnesota The Collaborative Pediatric Critical Care Research Network (CPCCRN) has been critical in building the knowledge base of pediatric critical care medicine. The overall aim of this site proposal is for the University of Minnesota Masonic Children's Hospital (UMMCH), under the leadership of Site Principal Investigator, Marie Steiner, MD, MS, to join this expanded iteration of CPCCRN. UMMCH is a free-standing, quaternary care, academic children's hospital located in Minneapolis, MN, serving children and families across a diverse range of racial, ethnic, and socioeconomic backgrounds. It has a 24-bed mixed medical/surgical and cardiac pediatric intensive care unit and offers the full spectrum of pediatric and surgical subspecialty services. UMMCH has a strong history of clinical research and innovation in conjunction with the resources of the University of Minnesota, the state's land grant university. Pediatric critical care research includes numerous completed and ongoing studies championed by multiple faculty, including the Co-Investigators for this grant. With increasing support from internal and external grants and the development of the Pediatric Device Innovation Center, the Division was third in the Department in launching new studies in 2019, behind Hematology/Oncology and HSCT. Children's Minnesota (Children's) will serve as our Ancillary Site under the leadership of Alberto Orioles, MD. Children's is a not-for-profit, freestanding children's hospital also located in Minneapolis, with a long-standing history of participation in critical care research, including several CPCCRN studies. Together, UMMCH and Children's will provide access to 55 pediatric ICU beds and over 3500 annual admissions, which captures the majority of critically ill children throughout the Upper Midwest and will facilitate participation in large clinical trials. The proposed “Personalized Immunomodulation in Sepsis-Induced Multiple Organ Dysfunction Syndrome (MODS)” trial addresses the hypothesis that immunosuppressed children will benefit from administration of granulocyte macrophage-colony stimulating factor and that children with hyperinflammation will benefit from targeted anti-inflammatory therapy. Benefit will be evaluated in terms of recovery from MODS, as well as short- and long-term health-related quality of life measures. This partnership has the knowledge and skills to successfully complete this trial, including sample collection and processing for immunophenotyping and collection of short- and long-term outcomes. Drs. Steiner and Orioles have the full support of their respective institutions to participate in CPCCRN and to prioritize patient recruitment and accrual to its studies. The institutions are strongly committed to collaboration with CPCCRN sites and the Data Coordinating Center to conduct the proposed and future research. Our clinical center and ancillary site will provide local mentorship for our highly talented young faculty and will support their participation in the central CPCCRN mentoring activities that are described in Section B.3 of the required CPCCRN Network Organizational Structure attachment to the Overall Component of this PL1 application.