Acute severe ulcerative colitis - clinical and translational studies

溃疡性结肠炎是一种对肠壁内层造成损害的疾病。20%的患者患有严重的这种情况。三分之一的患者在使用类固醇后没有好转，需要英夫利昔单抗，这是一种更强的药物，可以帮助避免紧急手术切除大肠。我们的研究旨在评估给予更大剂量或更频繁的英夫利昔单抗是否会提高患者好转的机会，并避免手术的需要。

Ulcerative colitis is a disease that causes damage to the lining of the bowel wall. Twenty percent of patients have a severe form of the condition. A third of patients do not get better with steroids and need infliximab, a stronger medication to help avoid emergency surgery to remove the large bowel. Our study aims to assess whether giving larger or more frequent doses of infliximab improves the chances of patients getting better and avoiding the need for surgery.