Pilot Projects Program

试点项目计划-摘要 试点项目计划(PPP)是COBRE在氧化剂、氧化还原平衡和 强调信号并支持我们的使命，即推动与氧化还原相关的创新基础研究和翻译研究 该中心的核心资源和技术。该计划的总体目标是继续重要的 我们从Cobre的前两个阶段获得了动力，提供并优先考虑短期 为旨在解决氧化还原和信号传递中的重要科学问题的试点研究提供资金 纪律。我们在此第三阶段应用程序中融入了PPP的创新功能，构建于 由南卡罗来纳州临床与翻译中心开发和维护的信息学工具和网络资源 作为CTSA支持基础设施，但为电子提交提供平台 以及审查申请和进度报告。购买力平价将继续提供并确定短期优先事项 通过竞争性方案提供资金，该方案将公开征集、同行评审和资金分成三部分 资助类别：发现：吸引初级教员而不需要事先获得校外资金来研究氧化剂、氧化还原平衡 和压力信号研究；新方向：吸引生物医学其他领域的知名研究人员 研究；以及可行性：使老牌氧化还原调查人员能够探索代表 与他们目前得到资助的工作有很大的偏离。该计划的最终目标是提供足够的 为飞行员调查人员提供资源和培训，以开发足够的初步数据，以准备具有竞争力的 将直接使用一个或多个Cobre核心的外部赠款申请。我们的最终目标将是 利用这些资金来利用额外的资金和想法，以扩大参与和科学 中心的竞争力。申请申请将每年征求意见，提前4个月。 预计的颁奖日期。与资金授予有关的决定将基于严格和 模仿美国国立卫生研究院系统的独立三阶段同行审查程序。初步审查级别将为 包括对提案进行筛选，以验证申请是否符合资格标准。第二个将涉及一个 内部专家小组，其主要职能将是评估 申请。第三级审查将由外部咨询委员会进行。申请将被打分 使用NIH量表，并根据四个标准进行优先排序：1)研究质量(科学价值， 创新和影响)；2)与中心的使命相关，以及一个或多个科布雷的直接参与 研究计划中的核心；3)研究团队的资格，以领导研究工作以确保 外部资金和4)促进与中心成员的合作努力。我们计划资助两个新的 和(或)延续项目，每个项目每年50,000美元或75,000美元，用于一至两年的支助。我们也 设想公私合作伙伴关系将使调查人员能够在可持续的情况下形成合作的跨学科项目 研究可以转化为多名研究人员的计划拨款申请(例如，U或P奖--我们有 在获得U奖方面取得了成功，见整体部分)，这将对氧化还原和细胞产生长期影响 在马萨诸塞州南加州大学从事信号研究。

Pilot Projects Program - Abstract The Pilot Projects Program (PPP) is an integral component of the COBRE in Oxidants, Redox Balance and Stress Signaling and supports our mission to drive innovative redox-related basic and translational studies using the Center’s core resources and technologies. The overall goal of this program is to continue the significant momentum we have gained from the first two Phases of this COBRE by providing and prioritizing short-term funding for pilot studies that are designed to address important scientific questions in redox and signaling disciplines. We have incorporated innovative features of the PPP in this Phase III application, building on informatics tools and web resources developed and maintained by the South Carolina Clinical & Translational Institute (SCTR) that serve as CTSA-supported infrastructure, but provide a platform for electronic submission and review of applications and progress reports. The PPP will continue to provide and prioritize short-term funding through a competitive program which incorporates open solicitation, peer review and funding in three grant categories: Discovery: Attracting junior faculty without prior extramural funding to oxidants, redox balance and stress signaling research; New Direction: Enticing established investigators in other areas of biomedical research; and Feasibility: Enabling established redox investigators to explore an area that represents a significant departure from their currently funded work. The ultimate goal of the program is to provide adequate resources and training for pilot investigators to develop sufficient preliminary data to prepare a competitive extramural grant application that will directly utilize one or more of the COBRE cores. Our ultimate goal will be to use these funds to leverage additional funds and ideas that will expand participation and scientific competitiveness for the Center. Requests for applications will be solicited annually, four months in advance of the anticipated award date. Decisions related to the awarding of funds will be based on a rigorous and independent three-phase peer-review process that is modeled on the NIH system. The initial level of review will involve screening of proposals to verify that applications meet the eligibility criteria. The second will involve a panel of internal experts whose primary function will be to evaluate the scientific and technical merits of applications. A third level of review will be performed by the External Advisory Board. Applications will be scored using the NIH scale and prioritized according to four criteria: 1) Quality of the research (scientific merit, innovation, and impact); 2) Relevance to the mission of the Center and direct involvement of one or more COBRE Cores in the research plan; 3) qualifications of the research team to lead the research effort toward securing extramural funding and 4) stimulation of collaborative efforts with Center members. We plan to fund two new and/or continuation projects per year at $50,000 or $75,000 each for one to two years of support. We also envision that the PPP will enable investigators to form cooperative, interdisciplinary projects where sustainable studies can be turned into programmatic multi-investigator grant applications (e.g. U or P awards – we have been successful in garnering U awards, see Overall section) that will have a long-term impact on redox and cell signaling research at MUSC.