Einstein's Nathan Shock Center of Excellence in Basic Biology of Aging

爱因斯坦-内森休克中心（Einstein-Nathan Shock Center，E-NSC）的研究开发中心利用资源， 资助26项试点和可行性研究，其中大部分授予初级研究人员或建立 研究人员追求新的研究方向，在生物学老化或研究人员谁是新的老化。 其中，超过50%的获奖者表现出明显的成功成果， 资金和/或提交手稿和新的赠款申请。鉴于这一成功，我们打算继续 我们的目标是将P&F资金作为RDC可交付成果的一部分。这些P&F研究旨在 并将继续加强和支持Einstein和成员机构的E-NSC科学。P&F基金 将优先分配给优秀的初级或“新老”研究者。第二个主要目标 E-NSC一直在寻找有潜力过渡到老龄化研究的新教师，并提供 通过多个门户网站，包括赠款申请程序，不断向他们提供指导。为此我们 我们已经取得了很大的成功，因为我们已经吸引了年轻的研究人员，并为他们提供咨询， 成功获得了NIH/NIA的资助。此外，爱因斯坦新招募的几名教员 将他们的主要关注点转移到了衰老的基础生物学上。我们将继续利用现有的高级 研究人员在爱因斯坦指导和支持研究人员在他们的准备P&F应用程序和新的 P&F获奖者。RDC的第三个目标将是传达其重要的机会和可用的 资源，其中包括P& F、核心服务以及对学员和现有调查人员的指导。这将 通过各种平台发生，如衰老生物学课程，通过邀请讲座和研讨会，并通过 互动式社区活动，如爱因斯坦黑客和年度E-NSC小型务虚会。我们认为 RDC的活动加强了E-NSC社区对老龄化研究的积极性，吸引了新的老龄化研究人员， 相关的研究，并成功地促进新的研究努力在老龄化相关领域。老龄化被认为是 爱因斯坦领导层的一个关键优先事项，如机构承诺与预算P&F相匹配所示 基金，每年可用于P&F赠款的资金总额高达300，000美元。这将使资金在 每年至少有7-12个P&F项目。因此，在下一个拨款期内，我们会继续推动 已取得成功的方案，并推出以提高认识为主要目标的新方案 衰老过程在生物学的各个方面都无处不在。

The Research Development Core of the Einstein-Nathan Shock Center (E-NSC) has leveraged resources to fund 26 pilot and feasibility (P&F) studies, most of which were granted to junior investigators or established investigators pursuing novel research directions in the biology of aging or investigators who are new to aging. Of these, more than 50% of awardees demonstrated clear outcomes of success indicated by the acquisition of funds and/or submission of manuscripts and new grant applications. Given this success, we intend to continue with our objective to maintain P&F funding as part of the RDC deliverables. These P&F studies are designed to and will continue to enhance and support E-NSC science at Einstein and at member institutions. The P&F funds will be preferentially distributed to meritorious junior or ‘new to aging’ investigators. A second major objective of the E-NSC has been to identify new faculty who have the potential to transition to aging research and to provide continuous mentoring to them through multiple portals including the grant application process. To that end, we have had much success in that we have attracted and advised junior researchers who have applied for and successfully obtained funding from the NIH/NIA. Additionally, several newly recruited faculty to Einstein have shifted their primary focus to the basic biology of aging. We will continue to draw on established senior investigators at Einstein to mentor and support researchers in their preparation of P&F applications and new P&F awardees. The third objective of the RDC will be to communicate its important opportunities and available resources, which includes P&Fs, core services and mentoring to trainees and established investigators. This will occur through various platforms such as the Biology of Aging course, via invited talks and seminars, and through interactive community events such as the Einstein Hackathon and the annual E-NSC mini-retreats. We believe that RDC activities strengthen the E-NSC community active in aging research, attract new investigators to aging- related research, and successfully promote new research endeavors in aging-related areas. Aging is considered a key priority for the leadership at Einstein as shown by the Institutional commitment to match budgeted P&F funds, yielding up to $300,000 annually in total available funds for P&F grants. This will permit the funding of at least 7-12 P&F projects in any given year. Consequently, in the next funding period, we will continue to drive the programs that have been successful and introduce new programs with the primary objective of raising awareness about the omnipresence of the aging process in all aspects of biology.