Imaging/Histopathology (I/H) Core

项目总结(影像/组织病理学) 17名视觉科学家申请继续资助(持有13项符合条件的NEI R01资助)和 他们的人员将支持三个资源/服务核心和一个行政核心 合并后的眼科、视觉和解剖科学系(原眼科 和解剖学/细胞生物学系)。影像/组织病理学(I/H核心)将指导 作者Ryan Thummel博士是一名由R01资助的研究员，具有重要的成像专业知识。同舟共济 有了PI和两名研究助理，环境和进行视觉的能力 韦恩州立大学及其附属机构的研究将通过 优先安排NEI R01资助的调查人员、他们的工作人员和学生(本科生和 在影像和组织病理学的许多方面。位于Scott Hall的I/H内核 并且对于视觉科学家来说很容易获得，将提供视觉功能分析、嵌入 组织切片/冷冻切片和免疫染色，用于激光共聚焦扫描 显微镜、免疫荧光、OCT和其他细胞成像分析(例如，细胞存活率和 质膜电位的量化)，以及设备使用方面的培训。I/H核心将 促进NEI R01资助的研究人员之间的合作，优先事项减少 没有资金的同事。临床和翻译研究也将在NEI R01之间得到促进 资助新合并科室(OVAS)的研究人员和临床医生。I/H内核还 将以较低的优先级支持新的调查人员和/或其他人(例如，那些正在寻求 新的研究方向)或正在收集初步数据以用于NEI R01资助 呈件。

Project Summary (Imaging/Histopathology) Continuing funds are requested by 17 vision scientists (holding 13 eligible NEI R01 grants) and their personnel to support three resource/service cores and an administrative core in the newly merged Department of Ophthalmology, Visual and Anatomical Sciences (former Ophthalmology and Anatomy/Cell Biology Departments). The Imaging/Histopathology (I/H Core) will be directed by Dr. Ryan Thummel, an R01-funded investigator with significant imaging expertise. Together with the PI, and two research assistants, the environment and capability to conduct vision research at Wayne State University and affiliated institutions will be enhanced through prioritization of the work of NEI R01 funded investigators, their staff and students (graduate and fellows) in numerous aspects of Imaging and Histopathology. The I/H core, located in Scott Hall and readily accessible to vision scientists, will provide for visual function analysis, embedding, sectioning/cryosectioning and immunostaining of tissues, for confocal laser scanning, light microscopy, immunofluorescence, OCT and other cell imaging analyses (e.g., cell viability and quantification of plasma membrane potential), and train in equipment use. The I/H Core will foster collaboration among NEI R01 funded investigators primarily and at reduced priority for unfunded colleagues. Clinical and translational studies also will be fostered between NEI R01 funded investigators and clinicians in the newly merged department (OVAS). The I/H Core also will support, at reduced priority, new investigators, and/or others (e.g., those who are seeking new research directions) or who are collecting preliminary data to be used for NEI R01 grant submission.