Neonatal Research Network: the Lurie Children's - Northwestern University Study Center

项目总结 改善新生儿结局和解决母婴结局差异需要 在临床护理和研究方面具有卓越表现的国家中心，与社区合作解决 公平地面对这些挑战。这些基于种族和族裔的差异的存在，特别是在 孕产妇和婴儿死亡率以及早产，突出了复杂的产前和产后社会和生物 影响妊娠结局的因素。NICHD新生儿研究网络(NRN)，通过创建 地理位置多样的多机构研究基础设施，不断致力于改善健康 减少早产婴儿和其他高危情况下的已知差异。《卢里》 儿童-西北大学研究中心，由安和罗伯特大学新生儿科组成 芝加哥鲁里儿童医院和西北大学费恩伯格儿科 医学院，每年分娩12,000人，每年有1700人进入我们的148个NICU Lurie儿童医院和Prentice妇女医院的床位以及我们与合作伙伴在 西北母婴医学部研究中心。我们有悠久的临床传统 卓越、由调查员发起的多中心调查，致力于培养下一代 内科科学家，倡导促进健康公平。因此，我们处于有利地位，可以成为强有力的补充 作为NRN的临床中心。为了实现NRN的目标，Lurie儿童西北研究 中心将：1)利用Lurie儿童/西北大学现有的协同关系 芝加哥医疗中心和未得到充分服务的社区“促进多元化社区的更多参与” 人口“，并促进招募孕妇及其新生儿参加研究方案和便利 2)提出并参与新的临床研究和分析， 利用Lurie儿童-西北站点的独特资源；3)利用我们站点的有效 支持国家资源规划目标的组织结构和管理办法；4)建立和 实施符合以下要求和标准的高质量数据和生物样品收集流程 基于我们目前在这些过程中取得的成功的NRN；以及5)为科学合作做出贡献 在NICHD、NRN和MFMU临床中心以及数据协调中心中，支持 研究网络的目标。

PROJECT SUMMARY Improving neonatal outcomes and addressing outcome disparities for mothers and their infants require national centers with excellence in clinical care and research that partner with communities to address these challenges equitably. The existence of these disparities based on race and ethnicity, specifically in maternal and infant mortality and preterm birth, highlight the complex prenatal and postnatal social and biological factors that influence pregnancy outcomes. The NICHD Neonatal Research Network (NRN), by creating a geographically diverse multi-institutional research infrastructure, has an ongoing commitment to improving health outcomes and reducing known disparities in infants born preterm and in other high-risk situations. The Lurie Children’s - Northwestern University Study Center, comprised of the Division of Neonatology at the Ann & Robert H. Lurie Children’s Hospital of Chicago and the Department of Pediatrics at Northwestern University Feinberg School of Medicine, is anchored by 12,000 deliveries per year and 1700 admissions per year to our 148 NICU beds at Lurie Children’s Hospital and Prentice Women’s Hospital and our collaboration with our partners at the Northwestern Maternal-Fetal Medicine Units (MFMU) Study Center. We have a long-standing tradition of clinical excellence, investigator-initiated and multi-center investigation, a commitment to train the next generation of physician scientists, and advocacy to promote health equity. Thus, we are well-positioned to be a strong addition as a Clinical Center to the NRN. To achieve the goals of the NRN, the Lurie Children’s-Northwestern Study Center will: 1) capitalize on the existing synergistic relationships within the Lurie Children’s / Northwestern Medical Center and underserved neighborhoods of Chicago to “facilitate greater involvement of diverse populations” and promote recruitment of pregnant women and their newborns for study protocols and facilitate their retention through the follow-up period; 2) propose and participate in novel clinical studies and analyses that capitalize on unique resources at the Lurie Children’s-Northwestern site; 3) utilize our site’s effective organizational structure and management approach to support the objectives of the NRN; 4) establish and implement high-quality data and biospecimen collection processes that meet the requirements and standards of the NRN based on our current success with these processes; and 5) contribute to the scientific collaboration among the NICHD, the NRN and MFMU clinical centers, and the Data Coordinating Center to support the research networks’ objectives.