Genomics for Social Scientists: 2022-2027

项目摘要 在本申请中，我们建议继续R25 AG 053227社会科学家基因组学的目标， 每年举办两次夏季研讨会，一次为期一周的基因组学介绍，另一次为期4天， 研讨会侧重于表观遗传学。这使包括表观遗传学在内的课程数量增加了一倍 这是一个最近补充创建的课程。除了一系列扩展的基于 在我们发现特别适合在线教学的课程方面，这些课程将建立 社会和行为科学家理解和进行基因组（即DNA，表观遗传学， 端粒长度等）利用国家情报局资助的资源进行的研究，如健康与退休研究（HRS）， 爱尔兰老龄化纵向研究（TILDA），北方爱尔兰老龄化纵向研究队列 （NICOLA）和国家青少年到成人健康纵向研究（Add Health）。建议的R25 研究教育计划将扩大社会科学研究人员使用这些数据的机会， 将基因组学纳入他们的研究，1）提供两个年度面对面和虚拟培训研讨会， 动手实验组件，2）创建一系列在线教程，可以增强研讨会或作为 独立的练习，以及3）将这些自定义工具与网络上已有的资源（即 促进更有效地利用大多数社会科学家通常不知道的资源）。的课程和 辅助材料将侧重于为从事基因组学和生物学交叉领域工作的研究人员提供培训。 社会科学研究，使用HRS数据作为模型，但广泛适用于任何社会科学研究 基因组数据我们将涵盖基因组学的生物学概述，收集人口中的基因组材料- 的研究，以及介绍目前的质量控制指标和统计方法，研究 人类复杂的特征实践分析是每门课程的一个组成部分，将利用 HRS核心调查数据和文件类似于HRS遗传和表观遗传数据文件， 安全的虚拟桌面基础架构（Virtual Desktop Infrastructure，简称VDI）。我们的团队由社会科学和基因组学专家组成， 数据在他们自己的老化研究，包括收集，化验和分析基因组样本和数据。 此外，该团队在过去5年中在7个不同的课程中教授了180多名学生。评价 课程一直非常积极，每年的课程材料都有所改进和修改， 更好地满足学生的需求，并与时俱进地开发方法。学生 展示了对该领域产生影响的巨大潜力，发表了近400篇使用基因组数据的文章 到目前为止。最终，我们的目标是通过讨论和举例，我们将重点关注以下方面的独特之处： 分析遗传和表观遗传数据与社会科学数据相结合，以促进跨部门合作 研讨会与会者的纪律。

Project Summary In this application, we propose to continue the aims of R25 AG053227 Genomics for Social Scientists by offering two annual summer workshops, one a week-long introduction to genomics and another 4-day workshop focused on epigenetics. This doubles the number of courses offered by including the epigenetics course that was created with a recent supplement. In addition to an expanded series of online modules based on aspects of the course we have found particularly well-suited to online instruction, these courses will build the capacity of social and behavioral scientists to understand and conduct genomic (i.e. DNA, epigenetics, telomere length, etc.) research using NIA-funded resources, such as the Health and Retirement Study (HRS), The Irish Longitudinal Study on Ageing (TILDA), Northern Ireland Cohort for the Longitudinal study of Ageing (NICOLA), and The National Longitudinal Study of Adolescent to Adult Health (Add Health). Our proposed R25 Research Education Program will expand the opportunity for social science researchers using these data to integrate genomics into their research by 1) offering two annual in-person and virtual training workshops with a hands-on lab component, 2) creating a series of online tutorials that can augment the workshop or serve as stand-alone exercises, and 3) linking these custom tools with resources already available on the web (i.e. facilitating more efficient use of resources typically unknown to most social scientists). The courses and supporting material will focus on providing training for researchers working at the intersection of genomic and social science research, using HRS data as a model, but broadly applicable to any social science study with genomic data. We will cover a biological overview of genomics, collection of genomic material in population- based studies, as well as an introduction to current quality control metrics and statistical methods for studying human complex traits. Hands-on analysis is an integral part of each course and will utilize tutorial versions of the HRS core survey data and files similar to the HRS genetic and epigenetic data files accessed using a secure virtual desktop infrastructure (VDI). Our team consists of experts linking social science and genomic data in their own aging research, including collecting, assaying, and analyzing genomic samples and data. Moreover, this team has taught over 180 students in 7 different courses over the last 5 years. Evaluations of the course have been very positive and each year the course material has improved and been modified to better fit the needs of the students and stay up to date with developing methodologies. Students have demonstrated tremendous potential for impact on the field publishing nearly 400 articles using genomic data thus far. Ultimately our goal is that through discussion and by example we will focus on the unique aspects of analyzing genetic and epigenetic data in combination with social science data to facilitate collaboration across disciplines for the workshop attendees.