Neurobehavioral Evaluation Core

摘要 神经行为评估核心（NEC）的使命是为哥伦比亚特区提供智力和 发育障碍研究中心（DC-IDDRC）的研究人员与资源，以联系基础 神经发育障碍的生物学机制与行为和认知结果的测量 在人类和动物模型中。DC-IDDRC研究人员可以获得最先进的神经行为 在人类和同源动物模型中的评估工具，以整合临床前和临床研究， 与IDD相关的异常的遗传和神经生物学分析。NEC通过以下方式提高效率： 提供专家人员和测试工具的访问权限，这些是单个实验室或研究人员无法获得的。的 NEC由两个互补的子核心组成;人类神经行为核心（HNEC），由 麦迪逊贝尔博士和动物神经行为核心（ANEC）由约书亚科尔宾博士指导。主 NEC的目标是提供：（a）人力资源的总体愿景、规划、培训和实施 人类同源动物模型中的行为任务和补充行为评估 神经发育障碍，（B）开发、维护和实施最先进的平台和资源 对于人类和动物神经行为研究以及跨多个动物模型，（c）合作， 与所有DC-IDDRC核心集成，以解开从基因到电路到行为的神经生物学机制 （d）促进开展强有力的、可重复的和严格的科学研究， 对神经科学和缺碘症领域有重大影响的调查，（e）广泛传播调查结果， 通过出版物、演讲和国际会议论坛， (f)利用从人类和动物行为评估中获得的知识来测试和翻译研究结果 从长椅到床边这些目标将在以下具体目标中实现：（1）界定 IDDs对人类神经行为和动物行为相关性的影响，（2）扩大和 实施使用最先进的技术进行人类和动物行为评估，以及（3） 制定/确定对人类缺碘症变化敏感的纵向评估范例 和动物模型，这将是至关重要的监测干预研究的成功。NEC已 在分析人类和动物模型的一些神经发育方面的长期优势 包括自闭症谱系障碍、癫痫、胎儿酒精综合征和胎儿/新生儿脑损伤的疾病。 在过去的几年里，我们非常成功的动物模型研究已经阐明了细胞和分子 在这些普遍的条件下，生理和行为异常的潜在机制，而我们的 人类研究已经将大脑发育的非典型轨迹与其结构和行为联系起来， 相互关联在这些优势的基础上，我们日益多样化和复杂的人类和动物行为 评估平台也将广泛适用于许多神经发育状况。

Abstract The mission of the Neurobehavioral Evaluation Core (NEC) is to provide District of Columbia Intellectual and Developmental Disabilities Research Center (DC-IDDRC) investigators with resources to link underlying biological mechanisms of neurodevelopmental disorders with behavioral and cognitive outcomes as measured in humans and animal models. DC-IDDRC investigators have access to state-of-the-art neurobehavioral assessment tools in humans and cognate animal models to integrate preclinical and clinical studies with genetic and neurobiological analysis of abnormalities associated with IDDs. The NEC enhances efficiency by providing access to expert personnel and testing tools not available to individual labs or investigators. The NEC is comprised of two complementary subcores; the Human Neurobehavior Core (HNEC), directed by Madison Berl, PhD and the Animal Neurobehavior Core (ANEC) directed by Joshua Corbin, PhD. The primary objectives of the NEC are to provide: (a) overall vision, planning, training and implementation of human behavioral tasks and complementary behavioral assessments in cognate animal models of human neurodevelopmental disorders, (b) to develop, maintain and implement state of the art platforms and resources for human and animal neurobehavior investigation and across multiple animal models, (c) to collaborate and integrate with all DC-IDDRC cores to unravel neurobiological mechanisms from genes to circuits to behaviors underlying a host of IDDs, (d) to facilitate the conduct of robust, reproducible and rigorous scientific investigation with a high impact on the field of neuroscience and IDDs, (e) to disseminate findings broadly to the scientific and academic communities via publications, presentations and international conference forums, (f) to use the knowledge gained from human and animal behavior assessments to test and translate findings from the bench to the bedside. These goals will be achieved in the following specific aims: (1) To define the consequences of IDDs on human neurobehavior and animal behavioral correlates, (2) To expand and implement the use state-of-the-art technologies for human and animal behavior assessment and (3) To develop/identify longitudinal assessment paradigms that are sensitive to change in IDDs in humans and animal models and that will be critical for monitoring success of intervention studies. The NEC has long standing strengths in the analysis of humans and animal models of a number of neurodevelopmental disorders including autism spectrum disorders, epilepsy, fetal alcohol syndrome and fetal/neonatal brain injury. Over the past years, our highly successful animal model studies have elucidated cellular and molecular mechanisms underlying physiological and behavioral abnormalities in these prevalent conditions, while our human investigation has linked atypical trajectories of brain development to their structural and behavioral correlates. Building on these strengths, our increasing variety and sophisticated human and animal behavioral assessment platforms will also be widely applicable across a host of neurodevelopmental conditions.