Developmental Research Program (DRP)

摘要 为了使SPORE研究人员能够迅速开发新的研究机会， 为乳腺癌患者提供早期益处，并允许探索可能需要 虽然我们已作出重大努力，但尚未准备好获得全面的多年研究资助， 投入了相当大的精力和资源，这个孢子发展研究计划。执行 委员会与倡导者成员和内部咨询委员会一起选择供资提案 作为发展项目，基于其科学价值和与SPORE转化目标的相关性。 通过试点项目的资助，我们拓宽了研究范围，并允许高风险的探索 这些想法在乳腺癌的治疗、预防或基础生物学方面具有高产量的潜力。我们也 吸引具有各种专门知识的新调查人员，将其专门知识应用于问题， 乳腺癌研究中的问题，我们催化富有成效的合作，其中个人技能和 各种方法联合收割机结合起来，创造了任何一个调查人员都无法单独取得的进展。重要的是指出 指出，虽然只有$50，000每年要求从孢子基金为这一计划，和贝勒学院 医学部每年额外捐款50，000美元，以表彰这一外联工作的价值， 贝勒大学的癌症研究 自1992年我们的第一个乳房孢子奖以来，在26年的资助中，我们资助了106个发展中国家， 项目，为128份出版物供稿，并为85份成功的赠款提供基本的初步数据 有几个申请仍在审理中。本申请中的两个新的完整项目部分源自 开发项目的人这一机制补充了更大更长的- 长期定期研究项目，提供一定程度的灵活性，从而提高了SPORE的生产力 整体而言。

ABSTRACT To enable SPORE investigators to rapidly develop new research opportunities which could translate into early benefits for breast cancer patients, and to allow for exploration of new techniques which may require substantial efforts but which are nevertheless not ready for full scale multi-year research funding, we have devoted considerable effort and resources to this SPORE Developmental Research Program. The Executive Committee, together with the advocate members and the Internal Advisory Board, selects proposals for funding as Developmental Projects, based on their scientific merit and relevance to SPORE translational goals. Through the funding of pilot projects, we broaden the scope of research, and allow exploration of high-risk ideas that have the potential for high yields in treatment, prevention, or basic biology of breast cancer. We also attract new investigators with a wide variety of special expertise to apply their expertise to problems and questions in breast cancer research, and we catalyze productive collaborations in which individual skills and approaches combine to create progress that no single investigator could achieve alone. It is important to point out that, although only $50,000 per year is requested from SPORE funds for this program, and Baylor College of Medicine is contributing an additional $50,000 per year in recognition of the value of this outreach effort to cancer research at Baylor. During the 26 years of funding since our first Breast SPORE award in 1992, we funded 106 developmental projects, contributing to 128 publications and providing essential preliminary data for 85 successful grant applications with several still pending. Two of the new full projects in this application derived in part from developmental projects to Drs. Chang and Westbrook. This mechanism complements the larger and longer- term regular research projects, offering a degree of flexibility which leads to enhanced productivity for the SPORE as a whole.