Virus Egress Pathways

冠状病毒出口研究-病毒的溶酶体释放： 我们已经确定了冠状病毒利用的新的出口途径。我们已经发现这些病毒利用溶酶体被运输出细胞。在使用溶酶体的过程中，这些病毒破坏溶酶体功能。我们已经发现，这导致细胞生理学（包括抗原呈递）的严重缺陷，并可能导致观察到的临床异常。 其他正链病毒流出研究：我们有一种全新的病毒传播模式，即病毒在细胞外囊泡内连续或整体传播。我们正在研究这种形式的传播对宿主先天性和适应性免疫反应的影响。 我们还发现了一种新的传播方式和肠道病毒，包括诺如病毒，轮状病毒，星状病毒和其他新的复制位点。我们已经发现这些病毒在唾液腺中复制并通过唾液传播给其他人。这一发现是新颖的，具有重大的公共卫生意义。详细描述这一发现的手稿正在审查中。

Coronavirus Egress Research- lysosomal release of viruses: We have identified the novel egress pathway exploited by coronaviruses. We have found that these viruses use lysosomes to be transported out of the cell. In the process of using lysosomes these viruses disrupt lysosomal function. We have found that this leads to profound defects in cell physiology including antigen presentation and may lead to the observed clinical abnormalities. Other positive strand virus egress research: We have an entirely novel mode of viral transmission, whereby viruses are transmitted en masse or en bloc , inside extracellular vesicles. We are studying the impact of this form of transmission on the host innate and adaptive immune response. We also discovered a novel mode of transmission and a novel site of replication for enteric viruses including norovirus, rotavirus, astrovirus and others. We have found that these viruses replicate robustly in the salivary glands and transmit to others via saliva. This finding is novel and has significant public health implications. The manuscript detailing this discovery is under review.