Utilizing Community-Based Participatory Action Research Approaches to Inform Equitable OCD Genetics Research in Diverse Populations

项目摘要 强迫症遗传研究中的广泛种族差异阻碍了对遗传风险因素的理解， 导致遗传发现应用中的下游差异（例如，多基因风险评分）。缺乏 在强迫症遗传学研究中的代表性自然会引起为什么存在这种知识差距的问题。为 来自少数群体的个人，诸如医疗种族主义、文化适应障碍、 卫生系统和心理健康污名是充分研究和普遍讨论的促成因素， 美国生物医学研究的差距。然而，仅仅承认这些因素并没有 在解决这些差距方面取得了成功。更可能的原因包括文化缺陷 招聘战略和与社区利益攸关方的接触有限，无法制定研究方法， 反映研究对象的需求。例如强迫症的跨文化差异的发生 症状表现可能会阻碍个人相信自己有资格参与强迫症 4这表明，人口并不难接触，但很难接触。此外，有限 通常注意与少数群体建立联盟，以更好地了解如何最好地 让参与者参与强迫症遗传学研究，而不是简单地试图招募他们。调查 以社区为基础的行动研究（C-BPAR）等框架是有用的方法， 从以最好的方式让利益相关者以文化上的谦逊参与制定招聘战略。 因此，拟议的多样性培训补充，以支持一个有前途的当前博士后研究员 目前未参与LATINO研究（Ogechi Chidima Onyeka，Ph.D.）旨在提高父母补助金 通过利用C-BPAR，就与文化相关的最佳做法制定社区知情的建议， 招募拉丁美洲血统的人进行强迫症遗传学研究该提案还旨在扩大 研究人口包括确定针对非洲人后裔的招募战略（1） 在强迫症遗传学研究中也代表性不足，（2）确保拉丁/x的非洲后裔 和/或西班牙裔遗产也充分代表在这一研究领域。最后，获得的数据也将 为开展试点定量调查提供信息，以更好地了解利益相关者对强迫症遗传学的看法 基于社区知情关切的研究。

Project Abstract The wide ethnoracial disparity in genetic studies for OCD impedes understanding of genetic risk factors, leading to downstream disparities in the application of genetic findings (e.g., polygenetic risk scores). The lack of representation in OCD genetics research naturally begets questions as to why this knowledge gap exists. For individuals from minoritized populations, concerns such as medical racism, acculturation barriers, mistrust of health systems, and mental health stigma are well-studied and commonly discussed contributing factors of biomedical research disparities in the United States. However, acknowledging these factors alone has not demonstrated success in addressing these disparities. More probable causes include culturally-deficient recruitment strategies and limited interface with community stakeholders to develop research approaches that reflect the needs of the population under study. For example, the occurrence of cross-cultural differences in OCD symptom presentation may impede individuals from believing that they are even eligible to participate in OCD genetics research.4 This suggests that the population is not hard to reach, but hardly reached. Moreover, limited attention is often devoted to developing coalitions with minoritized communities to better understand how to best engage participants in OCD genetics research, rather than simply attempt to recruit them. Investigative frameworks such as Community-Based Participatory Action Research (C-BPAR) are helpful approaches to draw from to best involve stakeholders in developing recruitment strategies with cultural humility. Therefore, the proposed diversity training supplement in support of a promising current postdoctoral fellow not currently engaged in the LATINO study (Ogechi Chidima Onyeka, Ph.D.) aims to advance the parent grant by utilizing C-BPAR to develop community-informed recommendations on culturally-relevant best practices for recruiting individuals of Latin American descent for OCD genetics research. The proposal also aims to expand the study population to include identifying recruitment strategies for individuals of African descent as they are (1) also underrepresented in OCD genetics research, and (2) ensure that African-descended people of Latine/x and/or Hispanic heritage are also adequately represented in this field of study. Lastly, data obtained will also inform the development of a pilot quantitative survey to better understand stakeholders' views on OCD genetics research based on community-informed concerns.