A data-driven reconceptualization of the RDoC construct of working memory: Neural correlates of underlying factors and implications for schizophrenia

项目摘要 这是根据PA-21-071(研究补充资料)提出的行政补充申请 促进健康相关研究的多样性)，以支持研究生阶段医学博士/博士双学位 生物医学工程实习生，来自美国生物医学领域代表性不足的人群， 临床、行为和社会科学研究企业，如NOT-OD-20-031(美国国立卫生研究院通知)所定义 对多样性的兴趣)标准3、4和5中的C类。受训者将参与开发高- 数据处理和分析方法是赠款定义的研究活动的基础 R01MH120293，其目的是阐明工作记忆(WM)缺陷的机制。 精神分裂症(SCZ)通过识别由WM组成的认知功能(即WM亚结构) 应用血氧水平依赖(BOLD)功能研究SCZ患者的神经功能损害 磁共振成像(FMRI)。这份补充资料将进一步支持职业参与和教育 通过支持国内和国际会议旅行提供机会，受训人员将通过这些旅行介绍情况 他们的工作并探索在精神病学方面进行综合研究生研究和临床培训的机会， 在PI的网络支持下。本补充申请中建议的活动将产生丰富的 在精神科神经影像方面的多学科培训经验，并促进家长的目标 Grant，有可能更好地了解SCZ的WM缺陷及其潜在的方法 治疗。

Project Summary This is an application for an administrative supplement under PA-21-071 (Research Supplements to Promote Diversity in Health-Related Research), in order to support a graduate phase M.D./Ph.D. dual degree trainee in Biomedical Engineering who originates from an Underrepresented Population in the U.S. Biomedical, Clinical, Behavioral and Social Sciences Research Enterprise, as defined in NOT-OD-20-031 (Notice of NIH's Interest in Diversity) category C under criteria 3, 4, and 5. The trainee will engage in the development of high- throughput data processing and analysis methodologies underlying research activities defined by grant R01MH120293, the goals of which are to elucidate mechanisms underlying working memory (WM) deficits in schizophrenia (SCZ) by identifying constituent cognitive functions comprised by WM (i.e., WM subconstructs) and neural correlates of their impairment in SCZ using Blood-Oxygen-Level-Dependent (BOLD) functional Magnetic Resonance Imaging (fMRI). This supplement will further support career engagement and educational opportunities by supporting national and international conference travel, through which the trainee will present their work and explore opportunities for integrated post-graduate research and clinical training in psychiatry, with networking support from the PI. The activities proposed in this supplement application will produce a rich multidisciplinary training experience in psychiatric neuroimaging and advance the objectives of the parent grant, with potential to produce a better understanding of WM deficits in SCZ and potential methods their treatment.