Regulating axon guidance through local translation at adhesions

项目摘要 本研究补充，以促进健康相关研究的多样性（PA-21-071）是为了 支持Jordan Headen在我的实验室进行博士前培训。这项建议是一项 补充我目前资助的NIH R 01奖（NS 125146）。在建议中，我们提供了一个 原（父）R 01的摘要，候选人的研究计划，职业发展 为候选人制定计划，以及PI指导候选人的资格。海登女士 在波尔州立大学完成了生物学学士学位。期间 本科时，她在阿什利卡林斯基博士的神经科学实验室工作， 神经损伤后神经炎症的分子机制。作为 在大学期间，希登女士出版了一篇合著的出版物。海登女士的长期 职业生涯计划是成为一个独立的教师在学术界的研究重点 关于神经科学这一补充将为海登女士提供广泛的研究经验 分子和细胞神经生物学，专注于局部翻译的机制 在轴突的引导下。此外，本补充将为海登女士提供重点 职业发展培训。总的来说，本补充材料将提供提交 在她读博士的第三年开始时，编程并帮助她 实现她成为学术界神经科学教授的目标。

PROJECT SUMMARY This Research Supplement to Promote Diversity in Health-Related Research (PA-21-071) is to support Jordan Headen to pursue predoctoral training in my laboratory. This proposal is a supplement to my currently funded NIH R01 award (NS125146). In the proposal, we provide a summary of the original (parent) R01, a research plan for the candidate, a career development plan for the candidate, and the PI’s qualifications to mentor the candidate. Ms. Headen completed her Bachelor of Science degree in Biology at Ball State University. During her undergraduate, she worked in the Neuroscience laboratory of Dr. Ashley Kalinski, examining molecular mechanisms contributing to neuroinflammation after nerve injury. As an undergraduate, Ms. Headen published one co-authored publication. Ms. Headen’s long-term career plans are to become an independent faculty member in academia with a research focus on neuroscience. This supplement will provide Ms. Headen with extensive research experience in molecular and cellular neurobiology, focusing on mechanisms underlying local translation during axon guidance. Furthermore, this supplement will provide Ms. Headen with focused career development training. Overall, this supplement will provide the training needed to submit a strong F31 application at the beginning of her third year in the Ph.D. program and help her achieve her goal of becoming a neuroscience professor in academia.