COMPLETION OF DATA HARMONIZATION IN PREVENTION AND TREATMENT THROUGH A COMPREHENSIVE CARE CONTINUUM FOR HIV-AFFECTED ADOLESCENTS IN RESOURCE CONSTRAINED SETTINGS (PATC3H) PROGRAM

Eunice Kennedy Shriver国家儿童健康和人类发展研究所（NICHD）需要获得支持，以完成通过资源有限环境中受艾滋病毒影响的青少年综合护理连续体（PATC3H）方案进行预防和治疗的数据协调活动。通用数据元素的统一将促进PATC3H项目之间的数据共享和分析。 自2018年以来，NICHD和合作伙伴NIH研究所通过分阶段创新合作协议机制为巴西和撒哈拉以南非洲的八个PATC3H奖项提供资金，用于具有高度公共卫生意义的干预措施：预防高危青少年新的艾滋病毒感染，在艾滋病毒负担重的中低收入国家查明感染艾滋病毒的青年，将他们与护理机构联系起来，并让他们继续接受护理，并实现长期的病毒抑制。PATC3H研究人员正在评估针对多个层面的各种创新组合干预措施，包括个人，家庭，诊所，社区，结构以及教育和卫生系统。项目包括与当地机构和监管机构（包括政策和项目领导人）的合作，以推动实现研究目标，并最大限度地实现有效干预措施和最佳实践的可持续性。创建这些项目生成的数据集的互操作性需要在研究完成后跨PATC3H项目进行数据协调。

The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) requires support to complete data harmonization activities for the Prevention and Treatment through a Comprehensive Care Continuum for HIV-affected Adolescents in Resource Constrained Settings (PATC3H) Program. Harmonization of common data elements will facilitate data sharing and analysis across PATC3H programs. The NICHD and partner NIH Institutes have funded eight PATC3H awards in Brazil and sub-Saharan Africa since 2018 through a phased innovation cooperative agreement mechanism for interventions of high public health significance: prevention of new HIV infections among adolescents at risk and identification of youth living with HIV in low-to-middle income countries with high HIV burden, linking them to and retaining them in care, and achieving long-term viral suppression. PATC3H investigators are evaluating a variety of innovative combination interventions aimed at several levels, including individual, family, clinic, community, structural, and education and health systems. Projects include collaborations with local agencies and regulatory bodies, including policy and program leaders, to advance achievement of the research objectives, and to maximize implementation and sustainability of efficacious interventions and best practices. Creating interoperability of datasets generated by these projects requires data harmonization after study completion across PATC3H programs.