Non-human primate MHC and KIR Allele Discovery and Typing Technology Development

该计划的目标是发现新的NHP MHC I类、MHC II类、杀伤细胞免疫球蛋白样受体（KIR）和Fc受体（FcR）基因、位点和等位基因；开发基因分型技术，使NHP研究界可以免费获得；提供所有序列生成到niaid指定的，公开可用的数据库。其他重要目标是：i)开发和应用全基因组/全外显子组测序（WGS， WES分别）到MHC， KIR和FcR区域；ii)生成并公开可用的补充信息，包括：a)用于基因/等位基因发现或基因分型的引物和探针定义；b)用于基因发现和等位基因频率研究的动物家族关系。这一信息将支持NHP临床前模型移植和其他研究的发展和解释

The objective of this program is to discover new NHP MHC Class I, MHC Class II, Killer-cell Immunoglobulin like Receptor (KIR), and Fc Receptor (FcR) genes, loci, and alleles; develop genotyping technologies that will remain freely accessible to the NHP research community; provide all sequences generated to the NIAID-designated, publicly available databases. Other important goals are to: i) develop and apply whole genome/whole exome sequencing (WGS, WES respectively) to the MHC, KIR, and FcR regions; and ii) generate and make publicly available supplemental information, including: a) primer and probe definitions used in gene/allele discovery or genotyping; and b) familial relationships of animals used in gene discovery and allele frequency studies. This information will support the development and interpretation of transplantation and other studies in the NHP pre-clinical model