Mechanisms of B cell immunodominance to influenza virus

目前的流感疫苗对快速变化的病毒或来自动物宿主的病毒保护不力。我们将确定为什么高度保守的病毒易感位点，如血凝素“茎”结构域，目前的疫苗很难靶向，并将在人类流感的猕猴模型中评估新的基于血凝素茎的疫苗。我们的研究结果将指导下一代流感疫苗的合理设计。

Current influenza vaccines elicit poor protection against viruses undergoing rapid change or emerging from animal reservoirs. We will define the basis for why highly conserved sites of virus vulnerability, such as the hemagglutinin 'stem' domain, are poorly targeted by current vaccines and will assess novel hemagglutinin stem-based vaccines in macaque models of human influenza. Our results will guide the rational design of next-generation vaccines for influenza.