MECHANISMS OF MOTOR RECOVERY AFTER SUBTOTAL BRAIN INJURY

描述：中风是功能性残疾的主要原因， 令人震惊的经济和社会影响。在成人和非人类中 灵长类动物在选择性损伤后有很好的运动恢复 运动皮质或其下行通路。尽管有相当多的 成人大脑的功能可塑性--运动的机制 人们对急性缺血性脑损伤后的恢复知之甚少。这个 这一提议的主要目标是检验这样一个假设，即中央 运动恢复中的功能恢复机制是通过 完整运动区皮质脊髓投射的重组 位于大脑次全损伤的同侧。 这个项目有两个具体目标。首先，调查人员将 扣带回运动臂区皮质脊髓投射的研究 切除同侧前臂区域后的皮质(M3) 运动皮质(M1)。其次，他们将研究皮质脊髓投射。 从同侧M3的臂区开始偏侧隔离 切除上臂M1区、辅助运动皮质(M2)和 外侧运动前皮质。

DESCRIPTION: Stroke is a leading cause of functional disability with staggering economical and social impacts. In adult humans and non-human primates, there is excellent motor recovery after selective damage of the motor cortex or its descending pathways. Although there is considerable functional plasticity in the adult brain, the mechanisms underlying motor recovery following acute ischemic brain injury are poorly understood. The major goal of this proposal is to test the hypothesis that a central mechanism of functional restitution in motor recovery occurs through reorganization of the corticospinal projection from intact motor areas located ipsilateral to a subtotal brain lesion. There are two specific goals of this project. First, the investigators will study the corticospinal projection from the arm area of the cingulate motor cortex (M3) following resection of the ipsilateral arm area of the primary motor cortex (M1). Second, they will study the corticospinal projection from the arm area of M3 in lateralized isolation following ipsilateral resection of the arm areas in M1, the supplementary motor cortex (M2) and lateral premotor cortex.