LEPTIN AND HEMATOPOIESIS

描述：（改编自申请人的摘要）： 这个项目是开发瘦素在治疗中的应用， 治疗造血系统疾病和移植。 最近他们 已经发现瘦素会影响一个细胞的存活和扩张， 骨髓细胞群。 一个彻底的特征， 将进行瘦素对分级骨髓细胞的作用。 瘦素特异性靶细胞的谱系将被进一步研究。 阐明瘦素在造血中的功能作用， 追究 从第1阶段研究中获得的信息将 表明利用瘦素作为治疗剂的可行性 对于可移植祖细胞的离体扩增和体内扩增， 加速移植后的恢复。

DESCRIPTION: (Adapted from the Applicant's Abstract): The goal of this project is to develop therapeutic applications for leptin in treatment of hematopoietic diseases and transplantation. Recently they have found that leptin affects the survival and expansion of a population of bone marrow cells. A thorough characterization of the effect of leptin on fractionated bone marrow cells will be performed. The lineage of leptin specific target cells will be further delineated and the functional role of leptin in hematopoiesis will be investigated. Information obtained from this Phase 1 research will indicate the feasability of utilizing leptin as a therpeutic agent for the ex vivo expansion of trasnplantable progenitor cells and in vivo to accelerate recovery after transplantation.