ETHANE EXHALATION AS AN INDEX OF NEUROLOGICAL STRESS

描述(改编自《调查员摘要》)： 抗氧化防御剂在维持一般幸福感和最佳 在健康专家中，健康正变得越来越被认可 在普通民众中也是如此。此外，更高的自由水平 自由基的产生和随后对大分子的氧化损伤， 与越来越多的进行性神经系统疾病有关 阿尔茨海默病(AD)、帕金森氏病(PD)、 肌萎缩侧索硬化症、多发性硬化症和癫痫。 抗氧化疗法正在进行实验测试，以治疗上述所有问题 疾病。抗氧化剂的利用也被认为是一种可能的 降低美国结肠癌极高发病率的方法 各州。抗氧化剂的使用对某些人来说可能有特殊的价值。 人群中的危险部分，如吸烟者。这些加在一起， 问题表明，现在是促进 一种简便的总量参数定量化方法的研制 身体氧化剂状态。该应用程序计划开发一种廉价的、 便携式、紧凑型和易于使用的色谱盒，允许快速 以及对过期乙烷的准确定量分析。测量的方法 呼出的碳氢化合物气体构成了一种完全非侵入性的 评估活的有机体中的氧化应激。 建议的商业应用： 这个项目具有很高的商业潜力。该设备/产品可以 在从医疗到临床的广泛领域找到应用 健康中心、水疗中心和医生办公室的诊断科。

DESCRIPTION (Adapted from Investigator's Abstract): The importance of anti-oxidant defenses in the maintenance of general well-being and optimal health is becoming increasingly recognized both among health specialists and also among the general public. Furthermore, elevated levels of free radical generation and consequent oxidative damage to macromolecules, have been implicated in an increasing number of progressive neurological disoders such as Alzheimer's disease (AD), Parkinsons disease (PD), amyotrophic lateral sclerosis, multiple sclerosis and epilepsy. Antioxidant therapy is being tested experimentally for all the above diseases. Antioxidant utilization has also been proposed as a possible means of reducing the very high incidence of colon cancer in the United States. The use of antioxidants may be of especial value to certain high risk segments of the population such as smokers. Taken together, these issues suggest that this is an appropriate time to promote the development of a convenient means of quantitating the parameter of total bodily oxidant status. This application plans to develop an inexpensive, portable, compact and easily usable chromatographic kit to allow a rapid and accurate quantitative analysis of expired ethane. The measurement of exhaled hydrocarbon gases constitutes a totally non-invasive means of estimating oxidative stress in living organisims. PROPOSED COMMERCIAL APPLICATION: This project has a very high commercial potential. The device/product can find applications in wide ranging areas from medical and clinical diagnostics to health centers,spas and doctors' offices.