使用超极化 3HE 进行肺部功能 MRI-猫眼课题宝

使用超极化 3HE 进行肺部功能 MRI

批准号：

2030079

负责人：

JONATHAN M RICHARDSON

金额：

$10.0万

依托单位：

SCIENCE RESEARCH LABORATORY, INC.

依托单位国家：

美国

项目类别：

财政年份：

1997

资助国家：

美国

项目状态：

已结题

起止时间：

1997-05-01 至 1997-10-30

来源：

https://reporter.nih.gov/project-details/2030079

关键词：

biomedical equipment development clinical biomedical equipment contrast media functional magnetic resonance imaging helium inert gas lung imaging /visualization /scanning particle accelerators pulmonary circulation obstruction respiratory disorder diagnosis respiratory function

中文摘要

翻译

肺部成像历来由传统的X射线技术. 美国最广泛的成像研究仍然是胸部X光检查，估计每年进行1亿或更多。计算机断层扫描也能很好地描述肺的解剖和病理。然而，这些成像技术都不能提供任何显著的成像效果。深入了解肺功能和病理生理学。功能成像肺在历史上一直是核医学的领域。甚至磁共振成像技术，人脑的成像难以应用于肺。最近的研究表明，超极化的3He，这是没有放射性的，并且是化学惰性的，可以用作MRI造影剂，

英文摘要

Lung imaging has historically been dominated by conventional x-ray technology. The most wide-spread imaging study in America remains the chest x-ray, with an estimated 100 million or more performed each year. Computerized tomography also delineates lung anatomy and pathology well. However, neither of these imaging techniques provides any significant insight into lung function and pathophysiology. Functional imaging of the lungs has historically been the domain of nuclear medicine. Even magnetic resonance imaging, which has allowed spectacular functional imaging of the human brain has been difficult to apply in the lung. Recent work has shown that hyperpolarized 3He, which is not radioactive and which is chemically inert, can be used as an MRI contrast agent to

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