BRAIN TUMORS IN MICE EXPOSED TO 60 HZ MAGNETIC FIELDS

描述：本提案的总体目标是测试 持续暴露于电磁场可诱发或促进脑肿瘤假说 在动物中的发生率，无论是独立的还是与之相关的， 电离辐射的致癌作用。 这一目标的方式是 通过四个具体目标。 第一，评估 正常小鼠中毒性脑损伤的时间依赖性发生率 没有持续的电磁场照射 二是明确时间依赖性 正常小鼠中原发性脑肿瘤的发生率， 电磁场暴露。 第三是确定与时间相关的 放射治疗小鼠的原发性脑肿瘤， 电磁场暴露。 第四是检查与时间有关的发病率， 淋巴瘤累及对照组和放射治疗组小鼠的脑， 并且没有持续的EMF暴露。 预计这些研究 将导致一个重要的模型系统的发展，以定义 电磁场对脑癌发病率影响的本质和基本机制。

DESCRIPTION: The overall objective of this proposal is to test the hypothesis that continuous exposure to EMF can induce or promote brain tumor incidence in animals, either independent of or in association with, the carcinogenic effects of ionizing irradiation. The objective will be addressed through four specific aims. The first is to assess the time-dependent incidence of brain toxic injury in normal mice with and without continuous EMF exposure. The second is to define the time-dependent incidence of primary brain tumors in normal mice with and without continuous EMF exposure. The third is to determine the time-dependent incidence of primary brain tumors in radiation-treated mice with and without continuous EMF exposure. The fourth is to examine the time-dependent incidence of lymphoma involvement of the brain in control and radiation-treated mice with and without continuous EMF exposure. It is anticipated that these studies will lead to the development of an important model system to define the nature and basic mechanisms of EMF effects on brain cancer incidence.