INDUCED SENSITIVITY TO ODORANTS

该提案寻求Fogarty国际研究基金会的资助。 合作奖（FIRCA），以支持实验室和工作， 俄国同事拟议的研究是工作的延伸， 目前由美国国立卫生研究院资助。父母补助金 支持对缺乏化学感受器的人类的化学感受功能的研究。 嗅觉和嗅觉功能正常的人， 试图更全面地了解各种之间的相互作用 化学感受系统FIRCA的提案将扩大该项目， 包括对人类化学感受变化动物模型的研究。 具体而言，将在三个领域进行调查，即， 行为生物化学和神经解剖学行为工作将探索 暴露于化学物质对化学感觉功能的影响， 灵敏度生化实验将研究酶系统的变化 似乎是由于暴露于化学物质造成的。神经解剖学工作 将探索大脑的区域， 暴露于化学品。总之，这些研究将增加我们的 了解化学感受系统的正常功能。

This proposal seeks funding under the Fogarty International Research Collaboration Award (FIRCA) to support the laboratory and work of a Russian colleague. The proposed research is an extension of work that is currently funded by the National Institutes of Health. The parent grant supports investigations of chemosensory function in humans who lack a sense of smell and in those who possess normal smell function in an attempt to more fully understand the interactions between the various chemosensory systems. This FIRCA proposal will expand this project to include studies of animal models of variation in human chemosensation. Specifically, three areas of investigation will be pursued, i.e., behavioral, biochemical and neuroanatomical. Behavioral work will explore the effects of exposure to chemicals on chemosensory function and sensitivity. Biochemical experiments will study changes in enzyme systems that appear to result from exposures to chemicals. Neuroanatomical work will explore regions of the brain that become activated as a result of exposure to chemicals. Together, these studies will increase our understanding of normal functioning of chemosensory systems.