Mechanisms and consequences of cholinergic neuron degeneration in sleep apnea

该提案旨在了解阻塞性睡眠呼吸暂停（OSA）与阿尔茨海默病风险增加相关的病因。我们的实验结果将提供对疾病特征发展的清晰理解，因此我们的结果将直接与诊断，设计有效的策略来预防和/或治疗已知患有痴呆症风险增加的大量OSA患者直接相关。

This proposal aims to understand the aetiology by which obstructive sleep apnea (OSA) is associated with an increased risk of developing Alzheimer’s disease. The outcomes of our experiments will provide a clear understanding of the development of disease characteristics, and our results will therefore be directly relevant to diagnose, designing effective strategies to prevent and/or treat the the large population of OSA sufferers who are known to be at increased risk of developing dementia.