PRIMARY BREAST CANCER THERAPY GROUP

这项研究提案旨在使人们能够继续参与 初级乳腺癌治疗小组--NSABP。的总体具体目标 NSABP旨在提高患者的无病存活率和存活率 初发可手术的乳腺癌和结直肠癌。(见NSABP 总部拨款申请礼宾基本原理和总体 迄今为止的科学成就。) 这座山。自1976年2月以来，西奈医疗中心一直是NSABP的成员 并跟踪了394名之前随机服用长期辅助剂的患者 协议。我们希望将患者收益增加到每年85人。这个 这些患者进入NSABP方案将使更快速和 对当前治疗方案的有效性进行评估，并将提供 为未来研究的设计提供信息。 这座山。西奈医疗中心是一家致力于协助 关爱通过美国入境的俄罗斯移民 克利夫兰港。医疗中心位于一个不景气的城市 区域。贫困人口--其中大部分是黑人--利用 该机构的门诊部。我们为世界上最大的部分提供服务 克利夫兰的黑人人口。NSABP合作小组允许我们 为这些乳房和结肠患者提供最先进的护理 癌症。这两个少数群体在我们的患者中都有表现 应计费用。 Mt.Mt.西奈半岛是地理上八个卫星机构的核心 半径约为60英里。此外，首席调查员 将他的诊所仅限于乳房疾病，导致大量转诊 为半径约100英里的区域提供服务的基地。

This research proposal is designed to enable continued participation in the Primary Breast Cancer Therapy Group--NSABP. The overall specific aims of the NSABP are to improve disease-free survival and survival in patients with primary operable breast and colorectal cancers. (See the NSABP Headquarters grant application for protocol rationale and overall scientific achievements to date.) The Mt. Sinai Medical Center has been an NSABP member since February 1976 and has followed 394 patients previously randomized on long term adjuvant protocols. We expect to increase patient accrual to 85 per year. The entry of these patients into NSABP protocols will enable a more rapid and effective evaluation of current therapeutic regimens and will provide information for the design of future studies. The Mt. Sinai Medical Center is a health facility dedicated to assist with the care of Russian immigrants who enter into the United States through the Port of Cleveland. The Medical Center is located in a depressed urban area. The indigent population - the majority of which are blacks - utilize the institution's outpatient clinics. We serve the largest segment of the black population in Cleveland. The NSABP cooperative group allows us to deliver state of the art care to these patients with breast and colon cancer. Both of these minority groups have been represented in our patient accrual. Mt. Sinai is the nucleus for eight satellite institutions in a geographic radius of approximately 60 miles. In addition, the Principal Investigator limits his practice to only breast diseases, resulting in a large referral base which services an area with a radius of approximately 100 miles.