Mechanisms of Epithelial Damage by the Noxious Smoke Constituent Acrolein

由于恐怖分子越来越多地使用反应性化学品（如氯气），其对肺部的影响在全球毒理学界越来越受到关注。该项目的重点是丙烯醛，这是有机物燃烧产生的烟雾中存在的主要细胞毒性物质。我们将探索丙烯醛和高剂量烟雾导致肺失去防水性能的机制，并测试用药物预防这种损伤的方法。

Due to increasing use of reactive chemicals by terrorists (e.g. chlorine gas), their effects on the lung are receiving increasing attention in the global toxicology community. This project focusses on acrolein, the major cytotoxic substance present in smoke produced on combustion of organic matter. We will explore the mechanisms whereby acrolein and high doses of smoke cause the lung to lose its watertight properties, and also test ways of preventing such damage with drugs.