NEUROMEDICAL CORE

神经医学核心的主要目的是提供科学的领导，参与者评估，数据分析和解释的研究集中在临床流行病学，发病机制，和neuroAIDS的临床管理。为了支持这些研究，我们的核心资源目标是（1）对HNRC研究参与者进行结构化评估;（2）领导病例会议，对参与者进行分类，并召开多学科会议，以审查基于HNRC的研究进展;（3）与神经行为核心合作，分配共识神经认知诊断;以及（4）在我们的专业领域为参与者和工作人员提供建议。核心的科学目标总结了我们更好地理解和治疗HIV神经认知并发症的方法。我们建议：（1）描述神经认知并发症的发病率和免疫及病毒相关性;（2）描述血浆和CSF介质;（3）通过验证为国家神经艾滋病组织联盟开发的诊断方法来标准化其诊断;（4）调查其对医疗依从性的影响。在HNRC附属赠款的资助下，我们领导了专注于其发病机制和治疗的试验。核心的创新能力和协作能力是其最大的优势之一。我们的创新涵盖了从HIV相关神经认知综合征诊断的简化和标准化到免疫、抗毒性和抗病毒疗法在其治疗中的作用的研究。为了追求更广泛的科学目标，核心研究人员与杰出的病毒学家、国家临床试验组织和行业合作。该核心将成为支持新研究人员的资源，促进跨学科的协同作用，并扩大神经艾滋病研究的范围。

The primary aims of the Neuromedical Core are to provide scientific leadership, participant evaluation, and data analysis and interpretation for studies focused on the clinical epidemiology, pathogenesis, and clinical management of neuroAIDS. To support these studies our Core Resource Objectives are to (1) perform structured assessments of HNRC study participants; (2) lead case conferences to triage participants and multi- disciplinary conferences to review progress in HNRC-based studies; (3) assign consensus neurocognitive diagnoses in collaboration with the Neurobehavioral Core; and (4) advise participants and staff in our areas of expertise. The Core's Scientific Objectives summarize our approach to better understanding and treatment the neurocognitive complications of HIV. We propose to (1) described incidence rates and immune and viral correlates of neurocognitive complications; (2) describe the plasma and CSF mediators; (3) standardize their diagnosis by validating diagnostic worksheets developed for the National NeuroAIDS Tissue Consortium; and (4) investigate their impact on medical adherence. Under funding by an HNRC-affiliated grant, we lead trials focused on their pathogenesis and treatment. The Core's ability to innovate and work collaboratively are among its greatest strengths. Our innovations span a spectrum from simplification and standardization of the diagnosis of HIV-associated neurocognitive syndromes to investigation of the roles of immune, anti- toxic, and anti-viral-based therapies in their treatment. In the pursuit of our broader scientific goals, the Core investigators have collaborated with distinguished virologists, national clinical trials organizations, and industry. The Core will be a resource to support new investigators, foster synergism across disciplines, and extend the scope of neuroAIDS research.