CAMP Continuation Study / Phase 2 (CAMPCS2)

此申请是为多伦多患病儿童医院参与儿童哮喘 管理方案继续研究/第二阶段(CAMPCS/2)。CAMPCS/2的摘要和研究计划包含在华盛顿大学(Robert Strunk，PI)的申请书中。这项计划研究的具体目标是对这一患者群体进行持续的跟踪和评估，直至成年，以便更好地描述A.轻度至中度哮喘对肺生长和呼吸道重塑哮喘的影响，以及B.吸入皮质类固醇对最终成人身高的影响。这是一项长期的观察性研究。研究人群是患有轻度到中度哮喘的儿童，最初参加了哮喘治疗的安慰剂对照试验(CAMP研究)。多伦多夏令营中心自1993年作为儿童哮喘管理计划(CAMP)成立以来，一直是这项多中心研究的参与者。多伦多营地诊所致力于参加cAMP/CS2，并支持继续跟进cAMP患者。我们最初在CAMP中招募了125名患者，随后在CAMPCS中招募了109名患者，其中一名随后重新纳入。参与CAMPCS的家属和患者继续致力于这项研究，并表示有兴趣保持这种关系。因此，我们预计他们将通过CAMPCS/2继续参与，并对100%继续登记持乐观态度。CAMPCS的人员(PI)没有变化 和护士协调员在5年内没有变化)，他们也仍然致力于继续这项有价值的研究。因此，我们将继续收集高质量的数据。

This application is for the Toronto Hospital for Sick Children to participate in the Childhood Asthma Management Program Continuation Study/Phase 2 (CAMPCS/2). The abstract and research plan for CAMPCS/2 is included in the application from the Washington University (Robert Strunk, PI). The specific aims of the projected study are the continued follow up and evaluation of this patient population through to adulthood, in order to better describe the impact of a. mild to moderate asthma on lung growth and airway remodelling asthma, and b. inhaled corticosteroids on eventual adult height. This is a long term observational study. The study population are children with mild to moderate asthma, originally enrolled in a placebo controlled trial of asthma therapy (the CAMP study). The Toronto CAMP Centre has been a participant in this multi-centred study since its inception in 1993 as the Childhood Asthma Management Program (CAMP). The Toronto CAMP clinic is committed to participate in CAMP/CS2 and supports the continued follow up of CAMP patients. We initially enrolled 125 patients in CAMP, and subsequently enrolled 109 patients in CAMPCS, with one subsequently re-enrolling. The families and patients participating in CAMPCS continue to be committed to the study and have expressed an interest in maintaining this relationship. We therefore anticipate their continued involvement through CAMPCS/2, and optimistic for 100% continued enrollment. There have been no changes in CAMPCS personnel (PI and nurse coordinators unchanged in 5 years), and they too remain committed to continuing this valuable study. We will therefore continue to collect data of high quality.