COMMUNITY CLINICAL ONCOLOGY PROGRAM RESEARCH BASE

放射治疗肿瘤学组（RTOG）致力于成为社区临床肿瘤学计划（CCOP）的研究基地。本申请文件记录了当前RTOG癌症控制组织，cccop成员在其中参与癌症治疗研究和癌症预防与控制科学建议。RTOG凭借其在地方-区域癌症治疗和控制方面的经验和专业知识，将继续利用CCOP网络作为其癌症控制研究计划的主要组成部分之一，该计划侧重于对已治愈和潜在可治愈的癌症患者进行干预研究。本申请记录了过去两年RTOG内的癌症预防和控制（CPC）活动，包括已完成和正在进行的头颈部和皮肤干预研究，以及解决症状控制和化学预防的研究。此外，本提案还记录了CCOP成员参与RTOG治疗和癌症控制研究，以及RTOG成员参与癌症控制研究的情况。本建议将建议的癌症控制活动分为四个部分-干预，晚期效应正常组织（LENT），化学预防和补充替代医学（CAM）。干预性研究将继续主导方案协调会的活动；LENT计划将研究细胞因子功能障碍在预测晚期效应中的作用；化学预防计划将解决替代标记物在评估化学预防剂方面的潜力；补充替代医学项目将提供研究来验证目前的药物是否可以用作介入性药物。每个项目的发展将为CCOP成员提供更多的机会参与RTOG的研究活动，并向RTOG成员介绍一群经验丰富、热情的社区放射肿瘤学家。行政职能将包括癌症控制副主席，以及每个部门的主席。由疾病现场委员会的生活质量、经济影响、特殊人群和CCOP代表组成的指导委员会将评估和确定优先事项。成员委员会评估每个CCOP，以确保遵守NCI的所有要求。在启动这些癌症控制试验时，利用了RTOG的行政、协议、质量保证和数据管理单位，并将质量保证程序，包括现场审计，应用于社区网络。我们的目标是继续将CCOPs整合到RTOG中，以确保所有成员都有机会参与RTOG活动的各个方面，以促进最新科学信息向社区的传递。

The Radiation Therapy Oncology Group (RTOG) has committed itself as a Research Base for the Community Clinical Oncology Program (CCOP). This application documents the current RTOG cancer control organization within which the CCOP members participate in the areas of cancer treatment studies and cancer prevention and control scientific proposals. The RTOG, with its experience and expertise in local-regional cancer treatment and control, will continue to utilize the CCOP network as one of the major components of its cancer control research program, which focuses on intervention studies in the cured and potentially curable cancer patient. This application documents the Cancer Prevention and Control (CPC) activity within the RTOG over the past two years, including completed and current intervention studies for head and neck, and skin, as well as studies addressing symptom control and chemoprevention. In addition, this proposal documents she participation of CCOP members in RTOG treatment and Cancer Control studies, as well as the involvement of RTOG members in Cancer Control studies. This proposal divides the proposed cancer control activities into four sections -intervention, late effect normal tissue (LENT), chemoprevention and complementary and alternative medicine (CAM). The interventional studies will continue to dominate the CPC activities; the LENT program will study the role of cytokine dysfunction in predicting late effects; the chemoprevention program will address the potential of surrogate markers in evaluating chemopreventive agents; and the complementary alternative medicine program will provide studies to validate whether current agents can be utilized as interventional agents. The growth of each program will provide additional opportunities for CCOP members to participate in RTOG research activities and present the RTOG member with an experienced and enthusiastic group of community radiation oncologists. The administrative functions will include the Vice-Chair for Cancer Control, as well as the Chairs for each section. A Steering committee composed of Chairs of the QOL, Economic Impact, Special Population, and CCOP representation of the disease site committees will evaluate and set priorities. The Membership committee evaluates each CCOP to assure adherence to all NCI requirements. The Administrative, Protocol, Quality Assurance and Data Management Units of RTOG are utilized in initiating these cancer control trials, and the quality assurance procedures, including on-site audits, are applied to the community network. The goal is for the continued integration of the CCOPs into the RTOG to insure all members the opportunity to participate in all facets of RTOG activities in order to facilitate the transference of the latest scientific information into the community.