Fourth Biennial Arthritis Research Conference

本申请要求为第四届两年一度的关节炎研究会议提供部分资金，该会议将由关节炎基金会、美国风湿病学院、美国骨科医生学会、国家关节炎研究所以及肌肉骨骼和皮肤疾病联合主办。会议将于2003年6月27日至29日在科罗拉多的Keystone会议中心举行。参加人数将限制在400人。所有已知的关节炎研究学员在北美被邀请参加。根据最有可能受益于会议的激励和富有成效的环境并为此作出贡献的专门知识和兴趣，邀请一些资深研究人员参加。特邀演讲者是杰出的研究人员，他们将在全体会议上发表演讲， 会议期间与学员互动。全体会议专门讨论所有与会者普遍感兴趣的主题，重点是基础免疫学的最新进展：从先天到适应性免疫反应以及同期的基础和临床科学研讨会。基础科学研讨会将致力于组织损伤的基本机制。主题包括类软骨新生细胞，组织损伤中的补体激活，软骨中的雌激素受体和促炎途径的再生和扩增。临床科学研讨会将集中在疼痛和炎症。主题包括绘制决定疼痛敏感性的基因位点;疼痛敏感性的性别差异，RA滑膜炎中免疫和炎症浸润的关键决定因素， 抗CD 20抗体作为治疗方法。12个讲习班将允许选定的受训人员介绍他们的研究。此外，还将举办两次海报展示会，所有剩余的受训人员将有机会展示他们的作品。总的目标是在非正式的气氛中提供一个互动的会议，促进关节炎发病机制和相关肌肉骨骼疾病的科学基础的许多方面的全面讨论。会议致力于促进来自不同背景的学员和资深科学家之间的有意义的互动，讨论当前的工作，激发新的倡议，并促进协作互动。

This application requests partial funding for the Fourth Biennial Arthritis Research Conference to be held under the joint sponsorship of the Arthritis Foundation, the American College of Rheumatology, American Academy of Orthopaedic Surgeons, the National Institute of Arthritis, and Musculoskeletal and Skin Diseases. The meeting will be held from June 27-29, 2003, at Keystone Conference Center, Keystone, Colorado. Participation will be limited to 400 attendees. All known arthritis research trainees in North America are invited to attend. Selected senior researchers are invited, based on expertise and interests that would most likely benefit from, and contribute to, the stimulating and productive environment of the Conference. Invited speakers are distinguished investigators who will present plenary lectures, chair sessions and workshops, and interact with trainees during the Conference. The plenary session is devoted to a topic of general interest to all participants, focusing on Recent Progress in Fundamental Immunology: From Innate to Adaptive Immune Responses and concurrent Basic and Clinical Science Symposiums. The Basic Science Symposium will be devoted to Basic Mechanisms of Tissue Injury. Topics include Lymphoid neogenes, Complement activation in tissue damage, Estrogen receptors in cartilage and RAGE and amplificaton of proinflammatory pathways. The Clinical Sciences Symposium will focus on Pain and Inflammation. Topics include Mapping gene loci that determine pain sensitivity; Sex differences in pain sensitivity, Key determinants of immune and inflammatory infiltrates in RA synovitis, Targeting B cells with anit-CD20 antibodies as a therapeutic approach. Twelve workshops will allow selected trainees to present their research. In addition, there will be two poster sessions, at which all remaining trainees will have an opportunity to present their work. The overall goal is to provide an interactive meeting in an informal atmosphere that facilitates comprehensive discussion of many aspects of the scientific basis of arthritis pathogenesis and related musculoskeletal diseases. The Conference strives to promote meaningful interaction between trainees and senior scientists from very diverse backgrounds to discuss current work, as well as stimulate new initiatives, and to foster collaborative interactions.