Gordon Research Conferences: Collagen 2003, 2005, 2007

描述(由申请人提供)： 戈登胶原蛋白会议自1970年以来每隔一年召开一次，因此2003年会议将纪念其33周年。胶原蛋白-戈登会议是为研究结缔组织的结构和病理学的研究人员举办的会议。它是一个对结缔组织生物学和疾病有共同兴趣的国际科学家小组进行互动的论坛。在胶原蛋白的基础生物学、发育和疾病方面，细胞外基质研究的重大发现经常在这次会议上首次报道。在2003-2007年胶原戈登会议上重点介绍的疾病将包括肌肉骨骼系统疾病、肌肉骨骼和皮肤疾病、风湿性疾病、纤维性疾病、肾脏和血管疾病以及衰老。胶原蛋白发育生物学和结构的各个方面都与眼睛的正常功能和疾病有关。在牙科研究领域，胶原蛋白在骨形成和牙齿结构的诱导中起着至关重要的作用。这些会议将强调有关胶原基因组结构、胶原的比较基因组学、胶原基因转录调控、蛋白质翻译后加工、细胞外基质蛋白的结构、功能和组装、这些蛋白质在发育过程中编码基因的调控，以及在人类和模式生物中胶原突变或基因缺失的表型和代谢后果的新信息。国际公认的结缔组织生物学家以及未来的研究人员将被邀请介绍他们最令人兴奋的工作。会议为在现有科学家之间以及在现有科学家和新科学家之间开展富有成效的合作提供了机会；这些合作反过来又进一步促进了该领域的科学进步。为了确保这次会议的成功，有最高水平的科学家参加，并介绍最具创新性的研究，他们要求为2003年、2005年和2007年的胶原戈登会议提供部分支持。这笔资金将用于支付受邀发言者和研究界年轻成员的部分与会者旅费和注册费。

DESCRIPTION (provided by applicant): The Collagen Gordon Conference has convened every other year since 1970, consequently the 2003 Conference will mark its 33rd anniversary. The Collagen Gordon Conference is a conference for investigators studying the structure and pathology of connective tissues. It is a forum for interaction of an international group of scientist with a common interest in connective tissue biology and diseases. Major discoveries in extracellular matrix research have often been reported for the first time at this conference in the basic biology, development, and diseases of collagen. Diseases highlighted at the 2003-2007 Collagen Gordon Conferences will include disorders of the musculoskeletal system, disease of muscle bone and skin, rheumatic diseases, fibrotic diseases, diseases of the kidneys and vasculature, as well as aging. All aspects of collagen developmental biology and structure are relevant to normal function and diseases of the eye. In the area of dental research, collagens play a vital role in the induction of bone formation and tooth structure. The conferences will emphasize new information regarding the structure of the collagen genome, comparative genomics of collagen, regulation of transcription of collagen genes, postranslational processing of proteins, structure, function and assembly of extracellular matrix proteins, the regulation of genes encoding these proteins during development, and the phenotypic and metabolic consequences of collagen mutations or gene deletion in humans and model organisms. Internationally recognized connective tissue biologists as well as up-and-coming investigators will be invited to present their most exciting work. The Conference has provided an opportunity for development of productive collaboration among established scientists and between established and new scientists; those collaborations have in turn further enhanced the scientific progress of the field. To ensure the success of this conference by participation of the highest caliber scientists and presentation of the most innovative research, they request funds for partial support of the 2003, 2005 and, 2007 Collagen Gordon Conferences. The funds will be used to partially defray conferee travel expenses and registration fees for invited speakers and for young members of the research community.