Enantioselective Fluorescent Sensors and Applications

描述：(申请人提供)本项目的目标是 手性对映体选择性识别荧光传感器的研制 有机化合物和药物分子。这些传感器将由 使用光学活性的联苯基手性分子和树枝状大分子。作为一种 这些对映体选择性荧光传感器的应用 用于不对称反应的席夫碱-路易斯酸催化剂的筛选 提出了用TMSCN对醛类化合物进行化学合成的方法。通过使用建议的 对映选择性荧光传感器，有望快速识别 只有一个的组合矩阵中的高对映选择性催化剂 或者两次荧光测量。对映体选择性荧光传感器将 也可用于高对映选择性的高通量搜索，方便 可用于其他几种不对称催化剂，且对环境无害 反应。传感器的用途将通过制备它们的刘易斯来扩大 酸性络合物。具有良好的配位能力和手性识别能力 Lewis酸络合物可实现对映体选择性的荧光识别 其他手性有机分子，如胺、氨基醇。醛， 酮和杂环。

DESCRIPTION: (provided by applicant) The objective of this project is to develop fluorescent sensors for the enantioselective recognition of chiral organic compounds and drug molecules. These sensors will be constructed by using optically active binaphthyl-based chiral molecules and dendrimers. As an application of these enantioselective fluorescent sensors, a combinatorial screening of the Schiff base-Lewis acid catalysts for the asymmetric reaction of aldehydes with TMSCN is proposed. With the use of the proposed enantioselective fluorescent sensors, it is expected to quickly identify the highly enantioselective catalysts in the combinatorial matrixes with only one or two fluorescence measurements. The enantioselective fluorescent sensors will also be used for the high through-put search of highly enantioselective, easily available, and environmentally benign catalysts for several other asymmetric reactions. The utility of the sensors will be expanded by preparing their Lewis acid complexes. The good coordination and chiral recognition ability of the Lewis acid complexes may allow the enantioselective fluorescent recognition of other chiral organic molecules such as amines, amino alcohols. aldehydes, ketones, and heterocycles.