Nanofabricated Particles for Biolistic Delivery

描述（由申请人提供）： 我们建议开发多功能复合颗粒，用于生物射弹应用中作为改进的DNA递送载体。这些颗粒将通过逐层技术使用纳米颗粒，聚合物和生物分子的受控组装来制造，其中核心和每个后续层为最终颗粒添加特定功能。密度、稳定性、表面积和表面化学组成将通过选择核和周围壳层的材料和尺寸来控制。当这些新的纳米制造的装置用于生物射弹应用中时，该过程的效率和再现性将大大提高。这些新的纳米粒子将在学术和商业研究社区的生物射弹转染系统的用户的广泛兴趣。

DESCRIPTION (provided by applicant): We propose the development of multi-functional composite particles for use as improved DNA delivery vehicles in biolistic applications. These particles will be fabricated using the controlled assembly of nanoparticles, polymers, and biomolecules via a layer-by-layer technique where the core and each subsequent layer add specific functionality to the final particle. The density, stability, surface area, and surface chemical composition will be controlled by the choice of material and dimensions of the core and surrounding shell layers. When these novel nano-fabricated devices are used in biolistic applications, the efficacy and reproducibility of the procedure will be greatly enhanced. These novel nanoparticles will be of broad interest to users of biolistic transfection systems in both academic and commercial research communities.