Corona Charge for Drug and DNA Deliver to Cancer Cells

描述(申请人提供)：这项拟议的R21探索性研究的长期目标是确定使用电晕电荷将治疗分子输送到癌细胞是否可行。这项研究的目的是制作、修改和现有的电晕电荷发生器，用于在体外的癌细胞模型中检测与这种能量传递方法相关的参数。药物和质粒DNA传递都将被检查。目的还包括使用电晕电荷将化疗药物和质粒DNA输送到小鼠模型中已建立的肿瘤中，以确定体内输送的可行性。如果成功，这项研究将证明低能量电晕源可以通过促进现有治疗剂进入癌细胞来补充现有的治疗剂。 这项研究与癌症有关，癌症是人类健康非常广泛的关注领域。这项研究的成功完成将为改进治疗癌症的化疗和DNA输送奠定基础。它还表明，电晕电荷可以用来将分子输送到正常组织，用于治疗癌症和其他类型的疾病。

DESCRIPTION (provided by applicant): The long-term objective of this proposed R21 exploratory study is to determine if the use of corona charge for delivering therapeutic molecules to cancer cells is feasible. The aims of the study include making modifying and existing corona charge generator for examining parameters related to this energy delivery method in a model cancer cell line in vitro. Both drug and plasmid DNA delivery will be examined. The aims also include using corona charge to deliver a chemotherapeutic agent and plasmid DNA to established tumors in a murine model in order to determine the feasibility of in vivo delivery. If successful, this study will demonstrate that a low energy corona source can be used to compliment existing therapeutic agent by facilitating their entry into cancer cells. This study relates to cancer which is a very broad area of concern for human health. Successful completion of the study will provide a foundation for improving chemotherapy and DNA delivery for treating cancer. It will also suggest, that corona charge can be used to deliver molecules to normal tissues for treating cancer and for treating other types of disease.