TRANSITIONS INTO ADULTHOOD--THE BALTIMORE STUDY

描述：(申请人摘要) 这是一项历时2000多年的纵向研究的扩展。 1985-86年首次招募的一年级学生作为流行病学样本，以及 从中学到中学每年进行一次评估。对于这项研究的扩展， 这些年轻人将在17、18岁的中位年龄接受采访， 以及19年。这个五年计划的主要目标有三个。 首先，我们将测试关于开始吸毒的时间有多早的假设 与晚期药物问题风险增加有关 青春期。第二，我们将检验关于童年的其他假说 可能影响风险水平、保护性、 以及弹性因素，包括行为问题、与 不正常的同伴，以及初次吸毒后可能发生的变化 (例如，在父母监测级别中)。一组可能的效果修饰符 要研究的中介因素包括假设的弹性因素，如 宗教信仰和社会纽带。第三，我们将检验替代假说。 关于吸烟和其他药物使用可能如何影响 精神障碍，并解释了随着时间的推移，精神共病。 这项工作将主要关注抑郁症、自残和自杀。 尝试。所有这三个目标都将协调一致地实现 时尚，借鉴了标准化数据收集的新浪潮 1997-2000年间的纵向流行病学样本。的长期目标是 该项目是确定相关的延展性特征 青春期涉及毒品的风险增加，以及后来吸毒的风险增加 依赖综合征。这些特点应该进一步证明 将评价作为今后研究中预防性干预的目标。

DESCRIPTION: (Applicant's Abstract) This is a proposed extension of a longitudinal study of more than 2000 first-graders first recruited as an epidemiologic sample in 1985-86, and assessed annually through middle school. For this extension of the study, these youths will be interviewed when they are at a median age of 17, 18, and 19 years. The main objectives of this 5 year project are threefold. First, we will test hypotheses about how early onset of drug use might be associated with an increase in risk for drug problems during late adolescence. Second, we will test alternative hypotheses about childhood conditions and processes that might influence levels of risk, protective, and resiliency factors, including conduct problems, affiliations with deviant peers, and possible changes that occur after initial drug-taking (e.g., in parent monitoring levels). The set of possible effect-modifiers and mediators to be studied include hypothesized resiliency factors such as religiosity and social bonds. Third, we will test alternative hypotheses about how tobacco smoking and other drug use might influence the onset of psychiatric disturbances and account for psychiatric comorbidity over time. This work will have a primary focus on depression, self-harm, and suicide attempts. All three of these objectives will be addressed in a coordinated fashion, drawing upon the new waves of standardized data gathering of this longitudinal epidemiologic sample between 1997-2000. The long-term goal of this project is to identify malleable characteristics associated with increased risk for drug involvement in adolescence and later risk of drug dependence syndromes. These characteristics should warrant further evaluation as the targets of preventive interventions in future studies.